European Journal of Chemistry 2014, 5(4), 671-675 | doi: https://doi.org/10.5155/eurjchem.5.4.671-675.1071 | Get rights and content






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Synthesis of 2-aryl substituted 2,3-dihydroquinazoline-4(1H)-ones under solvent free conditions using ionic liquid as a mild and efficient catalyst


Obaiah Obaiah (1) , Nandeesh Nagalingaiah Kebbahalli (2) , Raghavendra Manchigaiah Goravanahalli (3) , Pavankumar Siddalingaiah Chottanahalli (4) , Rangappa Subbegowda Kanchugarakoppal (5) , Mantelingu Kempegowda (6,*)

(1) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570006, India
(2) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570006, India
(3) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570006, India
(4) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570006, India
(5) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570006, India
(6) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570006, India
(*) Corresponding Author

Received: 10 Apr 2014 | Revised: 14 May 2014 | Accepted: 13 Jun 2014 | Published: 31 Dec 2014 | Issue Date: December 2014

Abstract


A simple, green and environmentally benign procedure has been developed for the synthesis of 2,3-dihydroquinazoline-4(1H)-ones in basic ionic liquid via the cyclocondensation of 2-amino benzamide with an aldehyde. This offers several advantages such as high yields, simple procedure, low cost, short reaction times, mild and solvent free condition.


Keywords


Aldehyde; Ionic liquid; Anthranilamide; Choline chloride; Solvent free condition; 2,3-Dihydroquinazoline4(1H)-ones

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DOI: 10.5155/eurjchem.5.4.671-675.1071

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Funding information


University Grants Commission, Government of India, The project vide No. F. No. 39-710-2011 (SR/dated 12-01-2010).

Citations

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Meta-analysis of ionic liquid literature and toxicology
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[2]. Satish Uttamrao Deshmukh, Kiran Ramesh Kharat, Gajanan Gulabrao Kadam, Rajendra Pundlikrao Pawar
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[3]. Jie Mou, Ninghai Chen, Yu Zhao, Hao Qi, Sihan Meng, Rui Xiang, Dongsheng Pei
An Aqueous Facile Synthesis of 2,3-Dihydroquinazolin-4(1H)-One Derivatives by Reverse Zinc Oxide Micelles as Nanoreactor
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[4]. Mariateresa Badolato, Francesca Aiello, Nouri Neamati
2,3-Dihydroquinazolin-4(1H)-one as a privileged scaffold in drug design
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DOI: 10.1039/C8RA02827C
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[5]. Sadashivamurthy Shamanth, Nagaraju Chaithra, Mahesha Gurukiran, Mahesha Mamatha, N. K. Lokanath, Kanchugarakoppal S. Rangappa, Kempegowda Mantelingu
I2-Catalyzed transformation of o-aminobenzamide to o-ureidobenzonitrile using isothiocyanates
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DOI: 10.1039/D0OB00118J
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[6]. Apurba Dutta, Krishnaiah Damarla, Ankur Bordoloi, Arvind Kumar, Diganta Sarma
KOH/DMSO: A basic suspension for transition metal-free Tandem synthesis of 2,3-dihydroquinazolin-4(1H)-ones
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How to cite


Obaiah, O.; Kebbahalli, N.; Goravanahalli, R.; Chottanahalli, P.; Kanchugarakoppal, R.; Kempegowda, M. Eur. J. Chem. 2014, 5(4), 671-675. doi:10.5155/eurjchem.5.4.671-675.1071
Obaiah, O.; Kebbahalli, N.; Goravanahalli, R.; Chottanahalli, P.; Kanchugarakoppal, R.; Kempegowda, M. Synthesis of 2-aryl substituted 2,3-dihydroquinazoline-4(1H)-ones under solvent free conditions using ionic liquid as a mild and efficient catalyst. Eur. J. Chem. 2014, 5(4), 671-675. doi:10.5155/eurjchem.5.4.671-675.1071
Obaiah, O., Kebbahalli, N., Goravanahalli, R., Chottanahalli, P., Kanchugarakoppal, R., & Kempegowda, M. (2014). Synthesis of 2-aryl substituted 2,3-dihydroquinazoline-4(1H)-ones under solvent free conditions using ionic liquid as a mild and efficient catalyst. European Journal of Chemistry, 5(4), 671-675. doi:10.5155/eurjchem.5.4.671-675.1071
Obaiah, Obaiah, Nandeesh Nagalingaiah Kebbahalli, Raghavendra Manchigaiah Goravanahalli, Pavankumar Siddalingaiah Chottanahalli, Rangappa Subbegowda Kanchugarakoppal, & Mantelingu Kempegowda. "Synthesis of 2-aryl substituted 2,3-dihydroquinazoline-4(1H)-ones under solvent free conditions using ionic liquid as a mild and efficient catalyst." European Journal of Chemistry [Online], 5.4 (2014): 671-675. Web. 5 Dec. 2020
Obaiah, Obaiah, Kebbahalli, Nandeesh, Goravanahalli, Raghavendra, Chottanahalli, Pavankumar, Kanchugarakoppal, Rangappa, AND Kempegowda, Mantelingu. "Synthesis of 2-aryl substituted 2,3-dihydroquinazoline-4(1H)-ones under solvent free conditions using ionic liquid as a mild and efficient catalyst" European Journal of Chemistry [Online], Volume 5 Number 4 (31 December 2014)

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DOI Link: https://doi.org/10.5155/eurjchem.5.4.671-675.1071

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