European Journal of Chemistry

Synthesis, characterization and in vitro biological evaluation of some new 1,3,5-triazine-chalcone hybrid molecules as Mycobacterium tuberculosis H37Rv inhibitors



Main Article Content

Subbarayal Reddy Dwarampudi
Gowri Sankar Dannana
Vasudeva Rao Avupati
Venkata Satyanarayana Murthy Bendi

Abstract

A novel series of 1,3,5-triazine-chalcone hybrid molecules (4a-ii) have been synthesized and evaluated in vitro for Mycobacterium tuberculosis H37Rv inhibitory potency using Alamar blue assay and the activity expressed as the minimum inhibitory concentration (MIC) in µg/mL. The antitubercular activity screening data revealed that the compound 4z demonstrated comparatively the most potent inhibitory activity, with MIC value 3.125 µg/mL. It is noteworthy that the compounds 4e, 4p and 4bb also showed appreciable inhibitory activity with MIC value 6.25 µg/mL. Most of the compounds displayed significantly promising activity and their structure-activity relationships were also discussed. This could be the remarkable starting point to develop new lead molecules with potential antitubercular activity.


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Dwarampudi, S. R.; Dannana, G. S.; Avupati, V. R.; Bendi, V. S. M. Synthesis, Characterization and in Vitro Biological Evaluation of Some New 1,3,5-Triazine-Chalcone Hybrid Molecules As Mycobacterium Tuberculosis H37Rv Inhibitors. Eur. J. Chem. 2014, 5, 570-576.

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