European Journal of Chemistry 2014, 5(4), 570-576. doi:10.5155/eurjchem.5.4.570-576.1098

Synthesis, characterization and in vitro biological evaluation of some new 1,3,5-triazine-chalcone hybrid molecules as Mycobacterium tuberculosis H37Rv inhibitors


Subbarayal Reddy Dwarampudi (1,*) , Gowri Sankar Dannana (2) , Vasudeva Rao Avupati (3) , Venkata Satyanarayana Murthy Bendi (4)

(1) Pharmaceutical Analysis and Quality Assurance Division, Andhra University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, Andhra Pradesh, India
(2) Pharmaceutical Analysis and Quality Assurance Division, Andhra University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, Andhra Pradesh, India
(3) Pharmaceutical Chemistry Division, Andhra University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, Andhra Pradesh, India
(4) Pharmacology Division, Andhra University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, Andhra Pradesh, India
(*) Corresponding Author

Received: 05 Jun 2014, Accepted: 02 Jul 2014, Published: 31 Dec 2014

Abstract


A novel series of 1,3,5-triazine-chalcone hybrid molecules (4a-ii) have been synthesized and evaluated in vitro for Mycobacterium tuberculosis H37Rv inhibitory potency using Alamar blue assay and the activity expressed as the minimum inhibitory concentration (MIC) in µg/mL. The antitubercular activity screening data revealed that the compound 4z demonstrated comparatively the most potent inhibitory activity, with MIC value 3.125 µg/mL. It is noteworthy that the compounds 4e, 4p and 4bb also showed appreciable inhibitory activity with MIC value 6.25 µg/mL. Most of the compounds displayed significantly promising activity and their structure-activity relationships were also discussed. This could be the remarkable starting point to develop new lead molecules with potential antitubercular activity.


Keywords


Hybrid molecules; Alamar blue assay; 1,3,5-Triaizine-chalcone; Structure activity relationship; Minimum inhibitory concentration; Mycobacterium tuberculosis H37Rv

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How to cite


Dwarampudi, S.; Dannana, G.; Avupati, V.; Bendi, V. Eur. J. Chem. 2014, 5(4), 570-576. doi:10.5155/eurjchem.5.4.570-576.1098
Dwarampudi, S.; Dannana, G.; Avupati, V.; Bendi, V. Synthesis, characterization and in vitro biological evaluation of some new 1,3,5-triazine-chalcone hybrid molecules as Mycobacterium tuberculosis H37Rv inhibitors. Eur. J. Chem. 2014, 5(4), 570-576. doi:10.5155/eurjchem.5.4.570-576.1098
Dwarampudi, S., Dannana, G., Avupati, V., & Bendi, V. (2014). Synthesis, characterization and in vitro biological evaluation of some new 1,3,5-triazine-chalcone hybrid molecules as Mycobacterium tuberculosis H37Rv inhibitors. European Journal of Chemistry, 5(4), 570-576. doi:10.5155/eurjchem.5.4.570-576.1098
Dwarampudi, Subbarayal, Gowri Sankar Dannana, Vasudeva Rao Avupati, & Venkata Satyanarayana Murthy Bendi. "Synthesis, characterization and in vitro biological evaluation of some new 1,3,5-triazine-chalcone hybrid molecules as Mycobacterium tuberculosis H37Rv inhibitors." European Journal of Chemistry [Online], 5.4 (2014): 570-576. Web. 16 Jan. 2019
Dwarampudi, Subbarayal, Dannana, Gowri, Avupati, Vasudeva, AND Bendi, Venkata. "Synthesis, characterization and in vitro biological evaluation of some new 1,3,5-triazine-chalcone hybrid molecules as Mycobacterium tuberculosis H37Rv inhibitors" European Journal of Chemistry [Online], Volume 5 Number 4 (31 December 2014)

DOI Link: https://doi.org/10.5155/eurjchem.5.4.570-576.1098

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