European Journal of Chemistry

PEG-400: An efficient and recyclable reaction medium for the synthesis of pyrazolo[1,5-a]pyrimidines



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Shankaraiah Guruvaiah Konda

Abstract

An efficient and convenient route is described for the synthesis of new pyrazolo [1,5-a] pyrimidine derivatives by the reaction of 4-(4’-chloro-phenylazo)-5-amino pyrazole with α,β-unsaturated carbonyl compounds (chalcones) using polyethylene glycol (PEG-400) as benign reaction medium. The advantage of this protocol includes the excellent yields, operational simplicity, short reaction times and avoidance of volatile organic solvents and expensive catalysts.


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Konda, S. G. PEG-400: An Efficient and Recyclable Reaction Medium for the Synthesis of pyrazolo[1,5-a]pyrimidines. Eur. J. Chem. 2014, 5, 676-680.

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