European Journal of Chemistry 2016, 7(1), 8-13 | doi: https://doi.org/10.5155/eurjchem.7.1.8-13.1333 | Get rights and content






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Synthesis, characterization and antibacterial evaluation of novel 2-mercaptobenzothiazole derivatives bearing 2-aminonicotinonitrile moiety


Monther Faisal Mahdi (1,*) , Rafah Fadhil Al-Smaism (2) , Noor Waleed Ibrahim (3)

(1) Department of Pharmaceutical Chemistry, College of Pharmacy, Al-Mustansiriyah University, Baghdad, 10001, Iraq
(2) Department of Pharmaceutical Chemistry, College of Pharmacy, Al-Mustansiriyah University, Baghdad, 10001, Iraq
(3) Department of Pharmaceutical Chemistry, College of Pharmacy, Al-Mustansiriyah University, Baghdad, 10001, Iraq
(*) Corresponding Author

Received: 13 Oct 2015 | Revised: 06 Nov 2015 | Accepted: 14 Nov 2015 | Published: 31 Mar 2016 | Issue Date: March 2016

Abstract


An efficient methods has been described for the synthesis of new 2-aminonicotinonitrile derivatives (6a-f) bearing benzothiazole nucleus by solvent free microwave or ultrasound irradiation. The reaction proceeds via one-pot four-component by cyclo condensation reaction of heterocyclic methyl ketones (4a), malononitrile, ammonium acetate and aryl aldehydes. Chalcones intermediate and final compounds were also synthesized by conventional methods, the result confirms that microwave method showed higher yield and purity than conventional one. The synthesized compounds were characterized by FT-IR spectroscopy and 1H NMR. Antibacterial activities of the synthesized compounds have been tested against four different types of bacteria; most of the tested compounds showed significant biological activities.


Keywords


2-MBT; Chalcones; Microwave; Malononitrile; Ultrasonic method; 2-Aminonicotinonitrile

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DOI: 10.5155/eurjchem.7.1.8-13.1333

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Funding information


Al Mustansiriyah Pharmacy College in Baghdad, Iraq

Citations

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How to cite


Mahdi, M.; Al-Smaism, R.; Ibrahim, N. Eur. J. Chem. 2016, 7(1), 8-13. doi:10.5155/eurjchem.7.1.8-13.1333
Mahdi, M.; Al-Smaism, R.; Ibrahim, N. Synthesis, characterization and antibacterial evaluation of novel 2-mercaptobenzothiazole derivatives bearing 2-aminonicotinonitrile moiety. Eur. J. Chem. 2016, 7(1), 8-13. doi:10.5155/eurjchem.7.1.8-13.1333
Mahdi, M., Al-Smaism, R., & Ibrahim, N. (2016). Synthesis, characterization and antibacterial evaluation of novel 2-mercaptobenzothiazole derivatives bearing 2-aminonicotinonitrile moiety. European Journal of Chemistry, 7(1), 8-13. doi:10.5155/eurjchem.7.1.8-13.1333
Mahdi, Monther, Rafah Fadhil Al-Smaism, & Noor Waleed Ibrahim. "Synthesis, characterization and antibacterial evaluation of novel 2-mercaptobenzothiazole derivatives bearing 2-aminonicotinonitrile moiety." European Journal of Chemistry [Online], 7.1 (2016): 8-13. Web. 1 Dec. 2020
Mahdi, Monther, Al-Smaism, Rafah, AND Ibrahim, Noor. "Synthesis, characterization and antibacterial evaluation of novel 2-mercaptobenzothiazole derivatives bearing 2-aminonicotinonitrile moiety" European Journal of Chemistry [Online], Volume 7 Number 1 (31 March 2016)

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DOI Link: https://doi.org/10.5155/eurjchem.7.1.8-13.1333

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