Synthesis, characterization and antibacterial evaluation of novel  2-mercaptobenzothiazole derivatives bearing 2-aminonicotinonitrile moiety

Monther Faisal Mahdi; Rafah Fadhil Al-Smaism; Noor Waleed Ibrahim

doi:10.5155/eurjchem.7.1.8-13.1333

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Published: Mar 31, 2016

DOI: https://doi.org/10.5155/eurjchem.7.1.8-13.1333

Keywords:

2-MBT, Chalcones, Microwave, Malononitrile, Ultrasonic method, 2-Aminonicotinonitrile

Section

Research Article

Issue

Vol. 7 No. 1 (2016): March 2016

Dates

Received 2015-10-13
Accepted 2015-10-29
Published 2016-03-31

Monther Faisal Mahdi

Department of Pharmaceutical Chemistry, College of Pharmacy, Al-Mustansiriyah University, Baghdad, 10001, Iraq

Rafah Fadhil Al-Smaism

Department of Pharmaceutical Chemistry, College of Pharmacy, Al-Mustansiriyah University, Baghdad, 10001, Iraq

Noor Waleed Ibrahim

Department of Pharmaceutical Chemistry, College of Pharmacy, Al-Mustansiriyah University, Baghdad, 10001, Iraq

Abstract

An efficient methods has been described for the synthesis of new 2-aminonicotinonitrile derivatives (6a-f) bearing benzothiazole nucleus by solvent free microwave or ultrasound irradiation. The reaction proceeds via one-pot four-component by cyclo condensation reaction of heterocyclic methyl ketones (4a), malononitrile, ammonium acetate and aryl aldehydes. Chalcones intermediate and final compounds were also synthesized by conventional methods, the result confirms that microwave method showed higher yield and purity than conventional one. The synthesized compounds were characterized by FT-IR spectroscopy and ¹H NMR. Antibacterial activities of the synthesized compounds have been tested against four different types of bacteria; most of the tested compounds showed significant biological activities.

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How to Cite

(1)

Mahdi, M. F.; Al-Smaism, R. F.; Ibrahim, N. W. Synthesis, Characterization and Antibacterial Evaluation of Novel 2-Mercaptobenzothiazole Derivatives Bearing 2-Aminonicotinonitrile Moiety. Eur. J. Chem. 2016, 7, 8-13.

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