European Journal of Chemistry

Synthesis of new derivatives of aryl-clonazepam via Suzuki Cross-coupling reaction

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Published: Jun 30, 2016
DOI: https://doi.org/10.5155/eurjchem.7.2.152-155.1403
Keywords:
Clonazepam, Diazepine ring, GABA receptor, 2D NMR spectroscopy, Benzodiazepine derivatives, Suzuki Cross-coupling reaction
Section
Research Article
Issue
Vol. 7 No. 2 (2016): June 2016
Dates
Received 2016-02-01
Accepted 2016-02-20
Published 2016-06-30


Main Article Content

Mohammed Abed Al-Hussein Salman
Department of Chemistry, College of Education, Al-Qadisiyah University, 58002, Diwaniya, Iraq
Nabeel Abed Abdul-Rida
Department of Chemistry, College of Education, Al-Qadisiyah University, 58002, Diwaniya, Iraq

Abstract

A new series of aryl clonazepam derivatives (11-16) have been synthesized by employing Suzuki Cross-coupling reaction, which includes the reaction of clonazepam with suitable derivative boronic acid at the presence of Pd(PPh3)4 as catalyst, and Na2CO3 as a base. The structures of the newly synthesized compounds were assigned by 1H, 13C and 2D NMR spectroscopic techniques.


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Salman, M. A. A.-H.; Abdul-Rida, N. A. Synthesis of New Derivatives of Aryl-Clonazepam via Suzuki Cross-Coupling Reaction. Eur. J. Chem. 2016, 7, 152-155.

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