European Journal of Chemistry 2016, 7(2), 152-155 | doi: https://doi.org/10.5155/eurjchem.7.2.152-155.1403 | Get rights and content






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Synthesis of new derivatives of aryl-clonazepam via Suzuki Cross-coupling reaction


Mohammed Abed Al-Hussein Salman (1) , Nabeel Abed Abdul-Rida (2,*)

(1) Department of Chemistry, College of Education, Al-Qadisiyah University, 58002, Diwaniya, Iraq
(2) Department of Chemistry, College of Education, Al-Qadisiyah University, 58002, Diwaniya, Iraq
(*) Corresponding Author

Received: 01 Feb 2016 | Accepted: 27 Feb 2016 | Published: 30 Jun 2016 | Issue Date: June 2016

Abstract


A new series of aryl clonazepam derivatives (11-16) have been synthesized by employing Suzuki Cross-coupling reaction, which includes the reaction of clonazepam with suitable derivative boronic acid at the presence of Pd(PPh3)4 as catalyst, and Na2CO3 as a base. The structures of the newly synthesized compounds were assigned by 1H, 13C and 2D NMR spectroscopic techniques.


Keywords


Clonazepam; Diazepine ring; GABA receptor; 2D NMR spectroscopy; Benzodiazepine derivatives; Suzuki Cross-coupling reaction

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DOI: 10.5155/eurjchem.7.2.152-155.1403

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Funding information


Al-Qadisiyah University, 58002, Diwaniya, Iraq

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How to cite


Salman, M.; Abdul-Rida, N. Eur. J. Chem. 2016, 7(2), 152-155. doi:10.5155/eurjchem.7.2.152-155.1403
Salman, M.; Abdul-Rida, N. Synthesis of new derivatives of aryl-clonazepam via Suzuki Cross-coupling reaction. Eur. J. Chem. 2016, 7(2), 152-155. doi:10.5155/eurjchem.7.2.152-155.1403
Salman, M., & Abdul-Rida, N. (2016). Synthesis of new derivatives of aryl-clonazepam via Suzuki Cross-coupling reaction. European Journal of Chemistry, 7(2), 152-155. doi:10.5155/eurjchem.7.2.152-155.1403
Salman, Mohammed, & Nabeel Abed Abdul-Rida. "Synthesis of new derivatives of aryl-clonazepam via Suzuki Cross-coupling reaction." European Journal of Chemistry [Online], 7.2 (2016): 152-155. Web. 25 May. 2020
Salman, Mohammed, AND Abdul-Rida, Nabeel. "Synthesis of new derivatives of aryl-clonazepam via Suzuki Cross-coupling reaction" European Journal of Chemistry [Online], Volume 7 Number 2 (30 June 2016)

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DOI Link: https://doi.org/10.5155/eurjchem.7.2.152-155.1403

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