European Journal of Chemistry 2017, 8(1), 82-84 | doi: https://doi.org/10.5155/eurjchem.8.1.82-84.1537 | Get rights and content






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Synthesis and antimicrobial activity of 1,3-bis-butyl-5-(4-iodophenyl)-1,3,5-triazacyclohexane


Leila Lefrada (1,*) , Randolf Köhn (2) , Souhila Malki (3) , Wissam Mazouz (4) , Ahcene Bouchemma (5) , Meriem Hadjem (6)

(1) Laboratory of Applied Chemistry and Materials Technology University Larbi Ben M’hidi of Oum El Bouaghi, 04000, Algeria
(2) Department of Chemistry University of Bath, Bath, BA2 7AY, United Kingdom
(3) Faculty of Exact Sciences, Department of Material Science, University Larbi Ben M’hidi of Oum El Bouaghi, Rue de Constantine, 04000, Algeria
(4) Department of Biology, Faculty of Sciences, University Badji Mokhtar, 2300 Annaba, Algeria
(5) Faculty of Exact Sciences, Department of Material Science, University Larbi Ben M’hidi of Oum El Bouaghi, Rue de Constantine, 04000, Algeria
(6) Faculty of Exact Sciences, Department of Material Science, University Larbi Ben M’hidi of Oum El Bouaghi, Rue de Constantine, 04000, Algeria
(*) Corresponding Author

Received: 30 Dec 2016 | Revised: 21 Jan 2017 | Accepted: 22 Jan 2017 | Published: 31 Mar 2017 | Issue Date: March 2017

Abstract


This work describes the synthesis, structural characterization and antibacterial activities of 1,3,5-triazacyclohexane type of new compound 1,3-bis-butyl-5-(4-iodophenyl)-1,3,5-triazacyclohexane. The new triazacyclohexanes (R3TAC) with mixed aryl and alkyl N-substituents are synthesized by the reaction of a 1:2 mixture of 4-iodoaniline and n-butylamine with formalin. The synthesized compounds were characterized by spectral analysis IR, 1H NMR and 13C NMR. The compound was screened for it’s antibacterial activity against Gram-positive and Gram-negative bacteria by the diffusion method on agar medium.


Keywords


Formalin; Synthesis; n-Butylamine; 4-Iodoaniline; Triazacyclohexane; Antibacterial activity

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DOI: 10.5155/eurjchem.8.1.82-84.1537

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Funding information


Laboratory of Applied Chemistry and Materials Technology of the University Larbi Ben M’hidi of Oum El Bouaghi, Research Fund (Project No: E03020130036), Algeria.

Citations

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[1]. Amel Ferhati, Achene Bouchemma, Mustapha Bouhenguel, Leila Lefrada, Assia Sid
Synthesis and characterization of 1,3-bis(2-fluorophenyl)-5-pentyl-1,3,5-triazinane
European Journal of Chemistry  8(1), 18, 2017
DOI: 10.5155/eurjchem.8.1.18-19.1510
/


References

[1]. Franchimont, A. P. N.; Erp, H. Rec. Trav. Chim. 1896, 15, 66-68.
https://doi.org/10.1002/recl.18960150204

[2]. Miller, J. G.; Wagner, E. C. J. Am. Chem. Soc. 1932, 54, 3698-3706.
https://doi.org/10.1021/ja01348a030

[3]. Baker, M. V.; Palermo, M. C.; Skelton, B. W.; White, A. H. ACS Catal. 2016, 6, 3008-3016.
https://doi.org/10.1021/acscatal.6b00542

[4]. Guido. S. PhD thesis, Technischen Universitat, Berlin, 1999.

[5]. Bouchemma, A.; McCabe, P. H.; Sim, G. A. J. Chem. Soc., Perkin Trans. 2 1989, 6, 583-587.
https://doi.org/10.1039/p29890000583

[6]. Latreche, S.; Bouchemma, A.; Bouacida S.; Bouhenguel M.; Mousser, A. Acta Cryst. E 2006, 62, o4676-o4678.
https://doi.org/10.1107/S1600536806030601

[7]. Latreche, S.; Bouchemma, A.; Bouacida S.; Bouhenguel M.; Mousser, A. Acta Cryst. E 2006, 62, o4674-o4675.
https://doi.org/10.1107/S160053680603546X

[8]. Latreche, S.; Bouchemma, A.; Bouacida S.; Bouhenguel M.; Mousser, A. Acta Cryst. E 2006, 62, o4960-o4962.
https://doi.org/10.1107/S160053680604147X

[9]. Khalaj, A.; Nakhjiri, M.; Negahbani, A. S.; Samadizadeh, M.; Firoozpour, L, Rajabalian, S.; Samadi, N.; Faramarzi, M. A.; Dibpour, N. A.; Shafiee, A.; Foroumadi, A. Eur. J. Med. Chem. 2011, 46, 65-70.
https://doi.org/10.1016/j.ejmech.2010.10.015

[10]. Pinkner, J. S.; Remaut, H.; Buelens, F.; Miller, E.; Aberg, V.; Pemberton, N.; Hedenstrom, M.; Larsson, A.; Seed, P.; Waksman, G.; Hultgren, S. J.; Almqvist, F. Natl. Acad. Sci. U. S. A. 2006, 103, 17897-17900.
https://doi.org/10.1073/pnas.0606795103

[11]. Meka, V. G.; Pillai, S. K.; Sakoulas, G.; Wennersten, C.; Venkataraman, L.; DeGirolami, P. C.; Eliopoulos, G. M.; Moellering, R. C.; Gold H. S. J. Infect. Dis. Drug. Targets 2004, 190, 311-317.

[12]. Chebbah, M.; Messai, A.; Bilge, D.; Bouchemma, A.; Parlak. C. J. Mol. Struc. 2017, 1129, 152-159.
https://doi.org/10.1016/j.molstruc.2016.09.060

[13]. Lefrada, L.; Bouchemma, A.; Bouhenguel, M.; Ferhati, A.; Chebbah, M. Eur. J. Chem. 2012, 3(4), 404-405.
https://doi.org/10.5155/eurjchem.3.4.404-405.657

[14]. Malki, S.; Lefrada, L.; Bouchemma, A.; Bouhenguel, M.; Chebbah, M.; Sid, A. Eur. J. Chem. 2016, 7(1), 137-138.
https://doi.org/10.5155/eurjchem.7.1.137-138.1337

[15]. Ferhati, A.; Bouchemma, A.; Bouhenguel, M.; Lefrada, L.; Assia, S. Eur. J. Chem. 2017, 8(1), 18-19.
https://doi.org/10.5155/eurjchem.8.1.18-19.1510

[16]. Ponce, A. G.; Fritz, R.; Valle, C.; Roura, S. I. Food Science. 2003, 36, 679-684.

How to cite


Lefrada, L.; Köhn, R.; Malki, S.; Mazouz, W.; Bouchemma, A.; Hadjem, M. Eur. J. Chem. 2017, 8(1), 82-84. doi:10.5155/eurjchem.8.1.82-84.1537
Lefrada, L.; Köhn, R.; Malki, S.; Mazouz, W.; Bouchemma, A.; Hadjem, M. Synthesis and antimicrobial activity of 1,3-bis-butyl-5-(4-iodophenyl)-1,3,5-triazacyclohexane. Eur. J. Chem. 2017, 8(1), 82-84. doi:10.5155/eurjchem.8.1.82-84.1537
Lefrada, L., Köhn, R., Malki, S., Mazouz, W., Bouchemma, A., & Hadjem, M. (2017). Synthesis and antimicrobial activity of 1,3-bis-butyl-5-(4-iodophenyl)-1,3,5-triazacyclohexane. European Journal of Chemistry, 8(1), 82-84. doi:10.5155/eurjchem.8.1.82-84.1537
Lefrada, Leila, Randolf Köhn, Souhila Malki, Wissam Mazouz, Ahcene Bouchemma, & Meriem Hadjem. "Synthesis and antimicrobial activity of 1,3-bis-butyl-5-(4-iodophenyl)-1,3,5-triazacyclohexane." European Journal of Chemistry [Online], 8.1 (2017): 82-84. Web. 6 Dec. 2020
Lefrada, Leila, Köhn, Randolf, Malki, Souhila, Mazouz, Wissam, Bouchemma, Ahcene, AND Hadjem, Meriem. "Synthesis and antimicrobial activity of 1,3-bis-butyl-5-(4-iodophenyl)-1,3,5-triazacyclohexane" European Journal of Chemistry [Online], Volume 8 Number 1 (31 March 2017)

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DOI Link: https://doi.org/10.5155/eurjchem.8.1.82-84.1537

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