European Journal of Chemistry 2017, 8(3), 195-202 | doi: https://doi.org/10.5155/eurjchem.8.3.195-202.1576 | Get rights and content






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Structural characterization, biological evaluation and DNA interaction of some potential drugs based on bifunctional aldehyde functionality


Mehwish Naz (1) , Zareen Akhter (2,*) , Ayesha Zaka (3) , Bushra Mirza (4) , Vickie McKee (5) , Ehsan Ullah (6) , Michael Bolte (7)

(1) Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
(2) Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
(3) Department of Biochemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
(4) Department of Biochemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
(5) Department of Chemical Sciences, Dublin City University, Glasnevin, Dublin, 9, Ireland
(6) Department of Biochemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
(7) Institut für Anorganische Chemie, Johann Wolfgang Goethe-Universität, Frankfurt/Main, D-60438, Germany
(*) Corresponding Author

Received: 21 Apr 2017 | Revised: 29 May 2017 | Accepted: 05 Jun 2017 | Published: 30 Sep 2017 | Issue Date: September 2017

Abstract


Recent work aimed at evaluating the possibility of enhancing biological activities by synthetically modifying bifunctional aldehyde structures. In this article, two series of bifunctional aldehydes were synthesized, structurally characterized (M-1A, M-1C and M-2A) using single crystal X-ray diffraction analysis. Several pharmacological properties like cytotoxic, antifungal, antibacterial, antioxidant and antitumor activities were also evaluated. In addition, bifunctional aldehyde-DNA interaction assay was examined by UV-Vis spectroscopy which revealed the DNA damaging behaviour of these aldehydes. The results of UV-Vis spectroscopy were supported by DNA damaging assay. The overall results reveal that bifunctional aldehyde moiety could be used as potential drug candidates.


Keywords


Hyperchromism; DNA damaging assay; Bifunctional aldehyde; Chemotherapeutic agent; Pharmacological activities; Bifunctional aldehyde-DNA interaction

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DOI: 10.5155/eurjchem.8.3.195-202.1576

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Supporting information


The Supplementary Material for this article can be found online at: Supplementary files

How to cite


Naz, M.; Akhter, Z.; Zaka, A.; Mirza, B.; McKee, V.; Ullah, E.; Bolte, M. Eur. J. Chem. 2017, 8(3), 195-202. doi:10.5155/eurjchem.8.3.195-202.1576
Naz, M.; Akhter, Z.; Zaka, A.; Mirza, B.; McKee, V.; Ullah, E.; Bolte, M. Structural characterization, biological evaluation and DNA interaction of some potential drugs based on bifunctional aldehyde functionality. Eur. J. Chem. 2017, 8(3), 195-202. doi:10.5155/eurjchem.8.3.195-202.1576
Naz, M., Akhter, Z., Zaka, A., Mirza, B., McKee, V., Ullah, E., & Bolte, M. (2017). Structural characterization, biological evaluation and DNA interaction of some potential drugs based on bifunctional aldehyde functionality. European Journal of Chemistry, 8(3), 195-202. doi:10.5155/eurjchem.8.3.195-202.1576
Naz, Mehwish, Zareen Akhter, Ayesha Zaka, Bushra Mirza, Vickie McKee, Ehsan Ullah, & Michael Bolte. "Structural characterization, biological evaluation and DNA interaction of some potential drugs based on bifunctional aldehyde functionality." European Journal of Chemistry [Online], 8.3 (2017): 195-202. Web. 23 Nov. 2020
Naz, Mehwish, Akhter, Zareen, Zaka, Ayesha, Mirza, Bushra, McKee, Vickie, Ullah, Ehsan, AND Bolte, Michael. "Structural characterization, biological evaluation and DNA interaction of some potential drugs based on bifunctional aldehyde functionality" European Journal of Chemistry [Online], Volume 8 Number 3 (30 September 2017)

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DOI Link: https://doi.org/10.5155/eurjchem.8.3.195-202.1576

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