European Journal of Chemistry

Synthesis of quinazolinones derivatives an antiproliferative agent against human lung carcinoma cells

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Published: Sep 30, 2017
DOI: https://doi.org/10.5155/eurjchem.8.3.317-320.1586
Keywords:
Ionic liquid, Green chemistry, 2-Aminobenzamide, Antiproliferative activity, Lung carcinoma A549 cells, 2, 3‐Dihydroquinazolin‐4(1H)‐one
Section
Short Communication
Issue
Vol. 8 No. 3 (2017): September 2017
Dates
Received 2017-05-20
Accepted 2017-06-16
Published 2017-09-30


Main Article Content

Satish Uttamrao Deshmukh
Department of Chemistry, Deogiri College, Aurangabad, 431005 (MS), India
Kiran Ramesh Kharat
Department of Biotechnology, Deogiri College, Aurangabad, 431005 (MS), India
Gajanan Gulabrao Kadam
Department of Chemistry, Shri Datta Arts, Commerce and Science College, Hadgaon, 431712 (MS), India
Rajendra Pundlikrao Pawar
Department of Chemistry, Deogiri College, Aurangabad, 431005 (MS), India

Abstract

2,3‐Dihydroquinazolin‐4(1H)‐one derivatives (3a-p) were synthesized in excellent yields. These compounds were screened for antiproliferative activity against A549 cells and were found as potent cytotoxicity. Compounds A4, A8, A10 found to be more promising antiproliferative against the lung carcinoma A549 cells. IC50 values for compounds A4, A8 and A10 were found to be 8.6, 8.9 and 8.1 μg/L against A549 cells, respectively.


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Deshmukh, S. U.; Kharat, K. R.; Kadam, G. G.; Pawar, R. P. Synthesis of Quinazolinones Derivatives an Antiproliferative Agent Against Human Lung Carcinoma Cells. Eur. J. Chem. 2017, 8, 317-320.

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