Polyethylene glycol (PEG-400) mediated synthesis of quinoxalines

Lingaiah Nagarapu, Raghu Mallepalli, Glory Arava, Lingappa Yeramanchi


A simple and highly efficient protocol for the synthesis of quinoxaline derivatives from various ortho-phenylenediamines with α-halo ketones under catalyst free conditions is reported by using polyethylene glycol (PEG-400) as an efficient recyclable medium without using any organic co-solvent or additive. This protocol gives wide range of quinoxaline derivatives with high yields.



α-Halo ketones; o-Phenylenediamines; Quinoxalines; Catalyst-free; Polyethylene glycol; PEG-400

European Journal of Chemistry, 1 (3), (2010), 228-231

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DOI: http://dx.doi.org/10.5155/eurjchem.1.3.228-231.172