European Journal of Chemistry 2018, 9(4), 317-321. doi:10.5155/eurjchem.9.4.317-321.1729

A mild and efficient method for the deprotection of trimethyl silyl alkynes using sodium ascorbate and copper sulphate


Ranjith Siddaraj (1) orcid , Raghu Ningegowda (2) orcid , Nanjunda Swamy Shivananju (3) orcid , Babu Shubha Priya (4,*) orcid

(1) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, Karnataka, India
(2) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, Karnataka, India
(3) Department of Biotechnology, Sri Jayachamarajendra College of Engineering, JSS Technical Institutions Campus, Mysore 570006, Karnataka, India
(4) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, Karnataka, India
(*) Corresponding Author

Received: 03 May 2018, Accepted: 08 Jul 2018, Published: 31 Dec 2018

Abstract


A competent and fast method for the deprotection of trimethyl silyl group was attained by using cheap, easily accessible, and nontoxic sodium ascorbate in combination with copper sulphate. The method labored was simple and effective for the cleavage of trimethyl silyl group from the protected trimethyl silyl alkynes to their corresponding alkyne derivatives. Wide functional group tolerance, shorter time period, simple procedure and high yields are the striking features of this protocol.


Keywords


Deprotection; Ethanol-water; Copper sulphate; Protecting group; Sodium ascorbate; Trimethyl silyl alkyne

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DOI: 10.5155/eurjchem.9.4.317-321.1729

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How to cite


Siddaraj, R.; Ningegowda, R.; Shivananju, N.; Priya, B. Eur. J. Chem. 2018, 9(4), 317-321. doi:10.5155/eurjchem.9.4.317-321.1729
Siddaraj, R.; Ningegowda, R.; Shivananju, N.; Priya, B. A mild and efficient method for the deprotection of trimethyl silyl alkynes using sodium ascorbate and copper sulphate. Eur. J. Chem. 2018, 9(4), 317-321. doi:10.5155/eurjchem.9.4.317-321.1729
Siddaraj, R., Ningegowda, R., Shivananju, N., & Priya, B. (2018). A mild and efficient method for the deprotection of trimethyl silyl alkynes using sodium ascorbate and copper sulphate. European Journal of Chemistry, 9(4), 317-321. doi:10.5155/eurjchem.9.4.317-321.1729
Siddaraj, Ranjith, Raghu Ningegowda, Nanjunda Swamy Shivananju, & Babu Shubha Priya. "A mild and efficient method for the deprotection of trimethyl silyl alkynes using sodium ascorbate and copper sulphate." European Journal of Chemistry [Online], 9.4 (2018): 317-321. Web. 19 Jun. 2019
Siddaraj, Ranjith, Ningegowda, Raghu, Shivananju, Nanjunda, AND Priya, Babu. "A mild and efficient method for the deprotection of trimethyl silyl alkynes using sodium ascorbate and copper sulphate" European Journal of Chemistry [Online], Volume 9 Number 4 (31 December 2018)

DOI Link: https://doi.org/10.5155/eurjchem.9.4.317-321.1729

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