European Journal of Chemistry 2019, 10(1), 26-29. doi:10.5155/eurjchem.10.1.26-29.1790

Synthesis, characterization and acute toxicity of new Schiff base derived from phenylethyl amine and 2-hydroxy naphthaldehyde


Ibtihal Hassan Hatim (1) orcid , Wasfi Aboud Al-Masoudi (2,*) orcid , Rashad Fadhil Ghadhban (3) orcid

(1) Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, University of Basrah, Basrah, 61001, Iraq
(2) Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, University of Basrah, Basrah, 61001, Iraq
(3) Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, University of Basrah, Basrah, 61001, Iraq
(*) Corresponding Author

Received: 16 Sep 2018, Accepted: 10 Nov 2018, Published: 31 Mar 2019

Abstract


There is an urgent need for the design and development of new and safer drugs, this has attracted organic chemists to synthesize new compounds with potential of biological and chemotherapeutic activities. Here we report, the condensation of phenylethylamine with 2-hydroxy naphthaldehyde yielded Schiff base derivative in good yield. Characterization of synthesized compound was carried by elemental analysis, IR, 1H-, 13C- and HSQC-NMR spectroscopy. The toxicity of the synthesized compound was determined using Balb/c mice model. Dixon’s up and down method was found to have an LD50 of 827.2 mg/kg of body weight, moderate toxicity.


Keywords


Schiff base; HSQC-NMR; Acute toxicity; IR spectroscopy; Phenylethylamine; 2-Hydroxy naphthaldehyde

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DOI: 10.5155/eurjchem.10.1.26-29.1790

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How to cite


Hatim, I.; Al-Masoudi, W.; Ghadhban, R. Eur. J. Chem. 2019, 10(1), 26-29. doi:10.5155/eurjchem.10.1.26-29.1790
Hatim, I.; Al-Masoudi, W.; Ghadhban, R. Synthesis, characterization and acute toxicity of new Schiff base derived from phenylethyl amine and 2-hydroxy naphthaldehyde. Eur. J. Chem. 2019, 10(1), 26-29. doi:10.5155/eurjchem.10.1.26-29.1790
Hatim, I., Al-Masoudi, W., & Ghadhban, R. (2019). Synthesis, characterization and acute toxicity of new Schiff base derived from phenylethyl amine and 2-hydroxy naphthaldehyde. European Journal of Chemistry, 10(1), 26-29. doi:10.5155/eurjchem.10.1.26-29.1790
Hatim, Ibtihal, Wasfi Aboud Al-Masoudi, & Rashad Fadhil Ghadhban. "Synthesis, characterization and acute toxicity of new Schiff base derived from phenylethyl amine and 2-hydroxy naphthaldehyde." European Journal of Chemistry [Online], 10.1 (2019): 26-29. Web. 23 Oct. 2019
Hatim, Ibtihal, Al-Masoudi, Wasfi, AND Ghadhban, Rashad. "Synthesis, characterization and acute toxicity of new Schiff base derived from phenylethyl amine and 2-hydroxy naphthaldehyde" European Journal of Chemistry [Online], Volume 10 Number 1 (31 March 2019)

DOI Link: https://doi.org/10.5155/eurjchem.10.1.26-29.1790

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