European Journal of Chemistry 2019, 10(4), 305-316 | doi: https://doi.org/10.5155/eurjchem.10.4.305-316.1901 | Get rights and content






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Square-wave voltammetric determination of drospirenone and ethinylestradiol in pharmaceutical dosage form using square wave technique


Ibrahim Hassan Habib (1) orcid , Mohammed Salem Rizk (2) orcid , Maha Sultan (3) orcid , Dalia Mohamed (4) orcid , Rehab Moussa Tony (5,*) orcid

(1) Department of Applied Organic Chemistry, Microanalytical Chemistry Laboratory, National Research Centre, Dokki, 12622, Giza, Egypt
(2) Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, EinHelwan, 11795, Cairo, Egypt
(3) Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, EinHelwan, 11795, Cairo, Egypt
(4) Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts, 11787, 6 October City, Egypt
(5) Chemical Industrial Development Company (CID), Giza, 12551, Egypt
(*) Corresponding Author

Received: 31 May 2019 | Revised: 29 Jul 2019 | Accepted: 01 Aug 2019 | Published: 31 Dec 2019 | Issue Date: December 2019

Abstract


Cathodic voltammetric behaviors of drospirenone and ethinylestradiol were used for the simultaneous determination of both drugs in bulk and in pharmaceutical formulation (Yasmin® tablets) without the interference of excipients. The determinations were made on hanging mercury dropping electrode using square-wave technique in a voltammetric cell containing 10 mL of 0.04 mole/L Britton-Robinson. After every aliquot addition, the solution was stirred for 10 s at 1000 rpm, rested for 10 s then square wave voltammetry mode was ramped from +100 to -1700 mV with scan rate of 100 mV/s, pulse amplitude of 50 mV and measurement time of 5 ms. Several factors such as pH, type of supporting electrolyte, pulse amplitude and scan rate were studied to optimize the condition for voltammetric determination of these drugs. With optimized experimental parameters, a good linearity was obtained for both drugs over a range of 1.36×10-6 to 1.91×10-7 mole/L and 6.75×10-8 to 6.07×10-7 mol/L of drospirenone and ethinylestradiol, respectively. Characterization of the proposed method was done according to International Conference on Harmonization, Q2B: Validation of Analytical procedures. The proposed method was statistically compared with the reference method and the results revealed no significant difference regarding accuracy and precision.


Keywords


Dissolution; Voltammetry; Drospirenone; Ethinylestradiol; Yasmin® tablets; Method validation

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DOI: 10.5155/eurjchem.10.4.305-316.1901

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Department of Applied Organic Chemistry, Microanalytical Chemistry Laboratory, National Research Centre, Egypt.

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How to cite


Habib, I.; Rizk, M.; Sultan, M.; Mohamed, D.; Tony, R. Eur. J. Chem. 2019, 10(4), 305-316. doi:10.5155/eurjchem.10.4.305-316.1901
Habib, I.; Rizk, M.; Sultan, M.; Mohamed, D.; Tony, R. Square-wave voltammetric determination of drospirenone and ethinylestradiol in pharmaceutical dosage form using square wave technique. Eur. J. Chem. 2019, 10(4), 305-316. doi:10.5155/eurjchem.10.4.305-316.1901
Habib, I., Rizk, M., Sultan, M., Mohamed, D., & Tony, R. (2019). Square-wave voltammetric determination of drospirenone and ethinylestradiol in pharmaceutical dosage form using square wave technique. European Journal of Chemistry, 10(4), 305-316. doi:10.5155/eurjchem.10.4.305-316.1901
Habib, Ibrahim, Mohammed Salem Rizk, Maha Sultan, Dalia Mohamed, & Rehab Moussa Tony. "Square-wave voltammetric determination of drospirenone and ethinylestradiol in pharmaceutical dosage form using square wave technique." European Journal of Chemistry [Online], 10.4 (2019): 305-316. Web. 20 Jan. 2020
Habib, Ibrahim, Rizk, Mohammed, Sultan, Maha, Mohamed, Dalia, AND Tony, Rehab. "Square-wave voltammetric determination of drospirenone and ethinylestradiol in pharmaceutical dosage form using square wave technique" European Journal of Chemistry [Online], Volume 10 Number 4 (31 December 2019)

DOI Link: https://doi.org/10.5155/eurjchem.10.4.305-316.1901

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