European Journal of Chemistry 2020, 11(2), 113-119 | doi: https://doi.org/10.5155/eurjchem.11.2.113-119.1968 | Get rights and content






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Synthesis and antibacterial activity of some new 1,2,4-triazole derivatives bearing carbohydrazide moiety


Haitham Husein Al-Sa’doni (1) orcid , Fatima-Azzahra Delmani (2) orcid , Abdullah Mohammed Al Balushi (3) orcid , Ala’a Hamed Al-Ahmad (4) orcid , Sondos Omar Alsawakhneh (5) orcid , Yaseen Ahmad Al-Soud (6,*) orcid

(1) Department of Chemistry, Faculty of Science, Al Al-Bayt University, Al-Mafraq, Jordan
(2) Department of Biology, Faculty of Science, Jerash University, 26150 Jerash, Jordan
(3) Department of Chemistry, Faculty of Science, Al Al-Bayt University, Al-Mafraq, Jordan
(4) Department of Chemistry, Faculty of Science, Al Al-Bayt University, Al-Mafraq, Jordan
(5) Department of Chemistry, Faculty of Science, Al Al-Bayt University, Al-Mafraq, Jordan
(6) Department of Chemistry, Faculty of Science, Al Al-Bayt University, Al-Mafraq, Jordan
(*) Corresponding Author

Received: 12 Feb 2020 | Revised: 29 Feb 2020 | Accepted: 24 Mar 2020 | Published: 30 Jun 2020 | Issue Date: June 2020

Abstract


In this study, a series of 1,2,4-triazol-3-carbohydrazide derivatives and compound of 1,2,4-triazole-3-(4H)-thion have been synthesized. Structures and purity of the new compounds were confirmed by the use of their chromatographic and spectral data besides microanalysis. Four different bacterial stains for the study of the biological activity of compounds 6g, 7c, 7g and 7i; two Gram-positive strains, and two Gram-negative strains have been used. Compound 6g was found to be the most active of the four tested compounds against Pseudomonas aeruginosa, Bacillus cereus and Staphylococcus aureus, with an inhibition zone diameter of 16, 9, and 10 mm, respectively. Calculating the minimal inhibitory concentration value (MIC) for the positive drugs who formed an inhibition zone in the agar well diffusion method, we found that both compounds 6g and 7i were the most active of the four tested compounds against Pseudomonas aeruginosa and Bacillus cereus with an MIC value of 0.5 µg/mL for both bacteria. These results suggest that these two compounds could be considered as potential antibacterial agents against a range of bacteria.


Keywords


Synthesis; 1,2,4-Triazoles; Carbohydrazides; Antibacterial activity; Broth dilution method; 1,2,4-Triazole-3-(4H)-thion

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DOI: 10.5155/eurjchem.11.2.113-119.1968

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Scientific Research Support Fund, Jordan.

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How to cite


Al-Sa’doni, H.; Delmani, F.; Al Balushi, A.; Al-Ahmad, A.; Alsawakhneh, S.; Al-Soud, Y. Eur. J. Chem. 2020, 11(2), 113-119. doi:10.5155/eurjchem.11.2.113-119.1968
Al-Sa’doni, H.; Delmani, F.; Al Balushi, A.; Al-Ahmad, A.; Alsawakhneh, S.; Al-Soud, Y. Synthesis and antibacterial activity of some new 1,2,4-triazole derivatives bearing carbohydrazide moiety. Eur. J. Chem. 2020, 11(2), 113-119. doi:10.5155/eurjchem.11.2.113-119.1968
Al-Sa’doni, H., Delmani, F., Al Balushi, A., Al-Ahmad, A., Alsawakhneh, S., & Al-Soud, Y. (2020). Synthesis and antibacterial activity of some new 1,2,4-triazole derivatives bearing carbohydrazide moiety. European Journal of Chemistry, 11(2), 113-119. doi:10.5155/eurjchem.11.2.113-119.1968
Al-Sa’doni, Haitham, Fatima-Azzahra Delmani, Abdullah Mohammed Al Balushi, Ala’a Hamed Al-Ahmad, Sondos Omar Alsawakhneh, & Yaseen Ahmad Al-Soud. "Synthesis and antibacterial activity of some new 1,2,4-triazole derivatives bearing carbohydrazide moiety." European Journal of Chemistry [Online], 11.2 (2020): 113-119. Web. 1 Dec. 2020
Al-Sa’doni, Haitham, Delmani, Fatima-Azzahra, Al Balushi, Abdullah, Al-Ahmad, Ala’a, Alsawakhneh, Sondos, AND Al-Soud, Yaseen. "Synthesis and antibacterial activity of some new 1,2,4-triazole derivatives bearing carbohydrazide moiety" European Journal of Chemistry [Online], Volume 11 Number 2 (30 June 2020)

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