European Journal of Chemistry 2011, 2(2), 235-237 | doi: https://doi.org/10.5155/eurjchem.2.2.235-237.205 | Get rights and content






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An improved synthesis of the alkaloid Luotonin-A employing ionic liquid and water as key solvents


Taterao Marutao Potewar (1) , Muthu Kumaradoss Kathiravan (2) , Aparna Surendra Chothe (3) , Kumar Venkatram Srinivasan (4,*)

(1) Division of Organic Chemistry, National Chemical Laboratory, Pune 411008, India
(2) Department of Pharmaceutical Chemistry, Sinhagad College of Pharmacy, Pune 411041, India
(3) Department of Pharmaceutical Chemistry, All India Shri Sivaji Memorial Society’s College of Pharmacy, Pune 411001, India
(4) Division of Organic Chemistry, National Chemical Laboratory, Pune 411008, India
(*) Corresponding Author

Received: 12 Jul 2010 | Revised: 01 Apr 2011 | Accepted: 15 Dec 2010 | Published: 30 Jun 2011 | Issue Date: June 2011

Abstract


Luotonin A is among the first known natural product possessing the heteroaromatic pyrroloquinazoline ring system. Although many syntheses have been reported for this compound, but they all have one or the other draw back such as a large number of steps, use of hazardous reagents like sodium hydride, low temperature reactions, and lengthy reaction time. Herein we report the synthesis of luotonin A achieved in five steps in which, two of the steps involved green solvents such as an ionic liquid and water as reaction media. In particular, we have achieved the reaction steps 1 and 3 involving the green solvents in much shorter reaction time than hitherto reported.

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Keywords


Ionic liquids; Luotonin A; Water; Pyrroloquinazoline; Volatile organic compounds; Anticancer activity

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DOI: 10.5155/eurjchem.2.2.235-237.205

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How to cite


Potewar, T.; Kathiravan, M.; Chothe, A.; Srinivasan, K. Eur. J. Chem. 2011, 2(2), 235-237. doi:10.5155/eurjchem.2.2.235-237.205
Potewar, T.; Kathiravan, M.; Chothe, A.; Srinivasan, K. An improved synthesis of the alkaloid Luotonin-A employing ionic liquid and water as key solvents. Eur. J. Chem. 2011, 2(2), 235-237. doi:10.5155/eurjchem.2.2.235-237.205
Potewar, T., Kathiravan, M., Chothe, A., & Srinivasan, K. (2011). An improved synthesis of the alkaloid Luotonin-A employing ionic liquid and water as key solvents. European Journal of Chemistry, 2(2), 235-237. doi:10.5155/eurjchem.2.2.235-237.205
Potewar, Taterao, Muthu Kumaradoss Kathiravan, Aparna Surendra Chothe, & Kumar Venkatram Srinivasan. "An improved synthesis of the alkaloid Luotonin-A employing ionic liquid and water as key solvents." European Journal of Chemistry [Online], 2.2 (2011): 235-237. Web. 30 Oct. 2020
Potewar, Taterao, Kathiravan, Muthu, Chothe, Aparna, AND Srinivasan, Kumar. "An improved synthesis of the alkaloid Luotonin-A employing ionic liquid and water as key solvents" European Journal of Chemistry [Online], Volume 2 Number 2 (30 June 2011)

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DOI Link: https://doi.org/10.5155/eurjchem.2.2.235-237.205

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