European Journal of Chemistry 2011, 2(3), 331-336 | doi: https://doi.org/10.5155/eurjchem.2.3.331-336.319 | Get rights and content






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Synthesis and antitumor activity of novel pyrazolo[1,5-a]pyrimidine derivatives


Mervat Mostafa El-Enany (1) , Mona Monir Kamel (2) , Omneya Mahmoud Khalil (3) , Hala Bakr El-Nassan (4,*)

(1) Pharmacology Chemistry Department, Faculty of Pharmaceutical Science and Pharmaceutical Industries, Future University, Cairo, 11562, Egypt
(2) Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt
(3) Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt
(4) Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt
(*) Corresponding Author

Received: 14 Nov 2010 | Revised: 21 Feb 2011 | Accepted: 30 Mar 2011 | Published: 30 Sep 2011 | Issue Date: September 2011

Abstract


A novel series of pyrazolo[1,5-a]pyrimidine-3-carbonitriles substituted with 7-amino, 7-substituted amino and 5-substituted amino groups was synthesized. Some of the newly synthesized compounds were tested in vitro on human colon tumor cell line (HCT116). Compound 14a displayed the highest activity among the tested compounds with IC50 that equals to 0.0020 μM.

2_3_331_336_800


Keywords


Pyrazole; 5-Aminopyrazole; Pyrazolo[1,5‐a]pyrimidine; Antitumor activity; Cytotoxic activity; HCT116

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DOI: 10.5155/eurjchem.2.3.331-336.319

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[5]. Shunan Kaping, Ivee Boiss, Laishram Indira Singha, Philippe Helissey, Jai N. Vishwakarma
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[6]. Elsherbiny H. El-Sayed, Khaled S. Mohamed
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[7]. Azza T. Taher, Lamia W. Mohammed
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How to cite


El-Enany, M.; Kamel, M.; Khalil, O.; El-Nassan, H. Eur. J. Chem. 2011, 2(3), 331-336. doi:10.5155/eurjchem.2.3.331-336.319
El-Enany, M.; Kamel, M.; Khalil, O.; El-Nassan, H. Synthesis and antitumor activity of novel pyrazolo[1,5-a]pyrimidine derivatives. Eur. J. Chem. 2011, 2(3), 331-336. doi:10.5155/eurjchem.2.3.331-336.319
El-Enany, M., Kamel, M., Khalil, O., & El-Nassan, H. (2011). Synthesis and antitumor activity of novel pyrazolo[1,5-a]pyrimidine derivatives. European Journal of Chemistry, 2(3), 331-336. doi:10.5155/eurjchem.2.3.331-336.319
El-Enany, Mervat, Mona Monir Kamel, Omneya Mahmoud Khalil, & Hala Bakr El-Nassan. "Synthesis and antitumor activity of novel pyrazolo[1,5-a]pyrimidine derivatives." European Journal of Chemistry [Online], 2.3 (2011): 331-336. Web. 3 Jun. 2020
El-Enany, Mervat, Kamel, Mona, Khalil, Omneya, AND El-Nassan, Hala. "Synthesis and antitumor activity of novel pyrazolo[1,5-a]pyrimidine derivatives" European Journal of Chemistry [Online], Volume 2 Number 3 (30 September 2011)

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DOI Link: https://doi.org/10.5155/eurjchem.2.3.331-336.319

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