European Journal of Chemistry 2012, 3(1), 21-25. doi:https://doi.org/10.5155/eurjchem.3.1.21-25.472

Synthesis and in-vitro antibacterial activity of some alkoxy based N-substituted-5-(furan-2-yl)-phenyl-bis-pyrazolines


Mamta Rani (1,*) , Mohamad Yusuf (2)

(1) Department of Chemistry, Punjabi University Patiala, Punjab, 147002, India
(2) Department of Chemistry, Punjabi University Patiala, Punjab, 147002, India
(*) Corresponding Author

Received: 26 May 2011, Accepted: 02 Aug 2011, Published: 31 Mar 2012

Abstract


Bis-pyrazoline darivatives (2a-e) built around the alkyl chains of varying length were synthesized in good yield by refluxing bis-chalcones (1a-e) with phenyl hydrazine in CH3COOH and ethanol. The structures of these compounds were elucidated by IR, 1H NMR, 13C NMR, Mass (ESI) spectrometries and their purities were confirmed by elemental analyses. The antibacterial activity of these compounds were evaluated by the disc diffusion assay against two Gram-positive and two Gram-negative bacteria and then the minimum inhibitory concentration of compounds were determined. The compounds 1,4-bis[1-(2-oxyphenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazole] butane (2a) and 1,10-bis[1-(2-oxyphenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazole]decane (2e) are better antibacterial agent as compared to Tetracycline and Gentamicin.

3_1_21_25_800


Keywords


Gentamicin; Tetracycline; Bis-chalcones; Bis-pyrazoline; Phenyl hydrazine; Antibacterial activity

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DOI: 10.5155/eurjchem.3.1.21-25.472

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[1]. Mamta Rani, Mohamad Yusuf
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[2]. Arindam Sarkar, Soumyadipta Rakshit, Subhash Chandra Bhattacharya
Interpreting the effect of confined cyclodextrin media on the FRET efficacy between Naproxen and a bio-active 3-pyrazolyl-2-pyrazoline derivative on the light of spectroscopic investigation appended by TD-DFT simulations and molecular docking analysis
Journal of Photochemistry and Photobiology A: Chemistry  343, 77, 2017
DOI: 10.1016/j.jphotochem.2017.04.024
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[3]. Soumya Sundar Mati, Sunandan Sarkar, Soumyadipta Rakshit, Arindam Sarkar, Subhash Chandra Bhattacharya
Probing the spectral response of a new class of bioactive pyrazoline derivative in homogeneous solvents and cyclodextrin nanocavities: a spectroscopic exploration appended by quantum chemical calculations and molecular docking analysis
RSC Advances  3(21), 8071, 2013
DOI: 10.1039/c3ra40749g
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[4]. Farouq Emam Hawaiz, Awaz Jamil Hussein, Mohammed Kareem Samad
One-pot three-component synthesis of some new azo-pyrazoline derivatives
European Journal of Chemistry  5(2), 233, 2014
DOI: 10.5155/eurjchem.5.2.233-236.979
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How to cite


Rani, M.; Yusuf, M. Eur. J. Chem. 2012, 3(1), 21-25. doi:https://doi.org/10.5155/eurjchem.3.1.21-25.472
Rani, M.; Yusuf, M. Eur. J. Chem. Synthesis and in-vitro antibacterial activity of some alkoxy based N-substituted-5-(furan-2-yl)-phenyl-bis-pyrazolines. 2012, 3(1), 21-25. doi:https://doi.org/10.5155/eurjchem.3.1.21-25.472
Rani, M., & Yusuf, M. (2012). Synthesis and in-vitro antibacterial activity of some alkoxy based N-substituted-5-(furan-2-yl)-phenyl-bis-pyrazolines. European Journal of Chemistry, 3(1), 21-25. doi:https://doi.org/10.5155/eurjchem.3.1.21-25.472
Rani, Mamta, & Mohamad Yusuf. "Synthesis and in-vitro antibacterial activity of some alkoxy based N-substituted-5-(furan-2-yl)-phenyl-bis-pyrazolines." European Journal of Chemistry [Online], 3.1 (2012): 21-25. Web. 21 Apr. 2018
Rani, Mamta, AND Yusuf, Mohamad. "Synthesis and in-vitro antibacterial activity of some alkoxy based N-substituted-5-(furan-2-yl)-phenyl-bis-pyrazolines" European Journal of Chemistry [Online], Volume 3 Number 1 (31 March 2012)

DOI: https://doi.org/10.5155/eurjchem.3.1.21-25.472

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