Synthesis of some novel Schiff bases containing 1,2,4-triazole ring

Akbar Mobinikhaledi, Naser Foroughifar, Mansooreh Khanpour, Sattar Ebrahimi

Abstract


4-Allyl-5-piridine-4-yl-4H-1,2,4-triazole-3-thiol was prepared under facile condition via the formation of 2-isonicotinoyl-N-allylhydrazinecarbothioamide. In addition, ethyl[(4-allyl-5-pyridine-4-yl-4H-1¸2¸4-triazole-3-yl)thio]acetate was synthesized via the reaction of 4-allyl-5-piridine-4-yl-4H-1,2,4-triazole-3-thiol with ethyl chloroacetate. 2-[(4-Allyl-5-pyridine-4-yl-4H-1,2,4-triazole-3-yl)thio]acetohydrazide obtained by using ethyl[(4-allyl-5-pyridine-4-yl-4H-1¸2¸4-triazole-3-yl)thio]acetate as a precursor by two steps, was converted to Schiff base derivatives, 6a-j. All synthesized compounds were characterized by elemental analyses, IR spectroscopy, 1H NMR and 13C NMR spectroscopy. The cis/trans conformers of E isomer were present in DMSO solution of compounds 6a-j.

1_1_33_36_800


Keyword(s)


1,2,4-triazole; Schiff bases; Acetohydrazide; Synthesis; Heterocyclic compounds

European Journal of Chemistry, 1 (1), (2010), 33-36

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DOI: http://dx.doi.org/10.5155/eurjchem.1.1.33-36.5


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