European Journal of Chemistry 2010, 1(1), 33-36 | doi: | Get rights and content


Synthesis of some novel Schiff bases containing 1,2,4-triazole ring

Akbar Mobinikhaledi (1,*) , Naser Foroughifar (2) , Mansooreh Khanpour (3) , Sattar Ebrahimi (4)

(1) Department of Chemistry, Faculty of Sciences, Arak University, Arak, IR-38156, Iran
(2) Department of Chemistry, Faculty of Sciences, Arak University, Arak, IR-38156, Iran
(3) Department of Chemistry, Faculty of Sciences, Arak University, Arak, IR-38156, Iran
(4) Department of Chemistry, Faculty of Sciences, Arak University, Arak, IR-38156, Iran
(*) Corresponding Author

Received: 24 Mar 2010 | Accepted: 24 Mar 2010 | Published: 31 Mar 2010 | Issue Date: March 2010


4-Allyl-5-piridine-4-yl-4H-1,2,4-triazole-3-thiol was prepared under facile condition via the formation of 2-isonicotinoyl-N-allylhydrazinecarbothioamide. In addition, ethyl[(4-allyl-5-pyridine-4-yl-4H-1¸2¸4-triazole-3-yl)thio]acetate was synthesized via the reaction of 4-allyl-5-piridine-4-yl-4H-1,2,4-triazole-3-thiol with ethyl chloroacetate. 2-[(4-Allyl-5-pyridine-4-yl-4H-1,2,4-triazole-3-yl)thio]acetohydrazide obtained by using ethyl[(4-allyl-5-pyridine-4-yl-4H-1¸2¸4-triazole-3-yl)thio]acetate as a precursor by two steps, was converted to Schiff base derivatives, 6a-j. All synthesized compounds were characterized by elemental analyses, IR spectroscopy, 1H NMR and 13C NMR spectroscopy. The cis/trans conformers of E isomer were present in DMSO solution of compounds 6a-j.



1,2,4-triazole; Schiff bases; Acetohydrazide; Synthesis; Heterocyclic compounds

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DOI: 10.5155/eurjchem.1.1.33-36.5

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How to cite

Mobinikhaledi, A.; Foroughifar, N.; Khanpour, M.; Ebrahimi, S. Eur. J. Chem. 2010, 1(1), 33-36. doi:10.5155/eurjchem.1.1.33-36.5
Mobinikhaledi, A.; Foroughifar, N.; Khanpour, M.; Ebrahimi, S. Synthesis of some novel Schiff bases containing 1,2,4-triazole ring. Eur. J. Chem. 2010, 1(1), 33-36. doi:10.5155/eurjchem.1.1.33-36.5
Mobinikhaledi, A., Foroughifar, N., Khanpour, M., & Ebrahimi, S. (2010). Synthesis of some novel Schiff bases containing 1,2,4-triazole ring. European Journal of Chemistry, 1(1), 33-36. doi:10.5155/eurjchem.1.1.33-36.5
Mobinikhaledi, Akbar, Naser Foroughifar, Mansooreh Khanpour, & Sattar Ebrahimi. "Synthesis of some novel Schiff bases containing 1,2,4-triazole ring." European Journal of Chemistry [Online], 1.1 (2010): 33-36. Web. 11 Aug. 2020
Mobinikhaledi, Akbar, Foroughifar, Naser, Khanpour, Mansooreh, AND Ebrahimi, Sattar. "Synthesis of some novel Schiff bases containing 1,2,4-triazole ring" European Journal of Chemistry [Online], Volume 1 Number 1 (31 March 2010)

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