European Journal of Chemistry

Synthesis of some novel benzimidazole derivatives and it's biological evaluation



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Doddarasinakere Kempaiah Ravishankara
Paduvalahippe Gowdegowda Chandrashekara

Abstract

A series of new benzimidazole derivatives have been synthesized by simple condensation reaction between benzimidazole derivatives and phenyl sulphonyl chloride derivatives. All these compounds were characterized by FT-IR, 1H NMR, MS and elemental analysis. These compounds were screened for antibacterial and antioxidant activities, respectively. The antibacterial activities were compared with the standard drug such as chlorophenicol and antioxidant activities were compared with the ascorbic acid.

3_3_359_362_800


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Ravishankara, D. K.; Chandrashekara, P. G. Synthesis of Some Novel Benzimidazole Derivatives and it’s Biological Evaluation. Eur. J. Chem. 2012, 3, 359-362.

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References

[1]. Goker, H.; Kus, C.; Abbasoglu, U. Arch. Pharm. (Weinheim) 1995, 328, 425-430.
http://dx.doi.org/10.1002/ardp.19953280506

[2]. Garuti, L.; Roberti, M.; Gentilomi, G. Il Farmaco 2000, 55, 35-39.
http://dx.doi.org/10.1016/S0014-827X(99)00117-2

[3]. Shinichi, K.; Kosaku, F.; Takashi, F. Chem. Abstr. PCT. Int. Appl. WO. 0105402. 2001, 134, 131531g.

[4]. Janssens, F.; Torremans, J.; Janssen, M.; Stokbroekx, R. A. J. Med. Chem. 1985, 28, 1925-1933.
http://dx.doi.org/10.1021/jm00150a028
PMid:4068010

[5]. Uzunoglu, S.; Tosun, A.; Ozden, T.; Yesilada, E. Hacettepe. Univ. Eczacilik. Fak. Derg. (Persian) 1997, 17, 17-24.

[6]. Fanqi, Q.; Xinrong, D.; Xinxiang, L.; Xin, L.; Xiaoling, H. J. Nat. Sci. 1998, 3, 201-204.

[7]. Sermin, U.; Bilge, C.; Tosun, A.; Fethi, S. M.; Berrin, O. Hacettepe. Univ. Eczacilik. Jak. Derg. (Persian) 1997, 17, 47-53.

[8]. Samuel, H. N.; Rida, S. M.; Badawey, E. A. M.; Fahmy, H. T. Y.; Ghozlan, H. A. Pharmazie 1997, 52, 346-350.
PMid:9183785

[9]. Laura, G.; Marinella, R.; Annalisa, P.; Emanuela, L. Bioorg. Med Chem. Lett. 2001, 11, 3147-3149.
http://dx.doi.org/10.1016/S0960-894X(01)00639-4

[10]. Habib, N. S.; El-Hawash S A. Il Farmaco 1989, 44, 1225-1232.
PMid:2699417

[11]. Anton, V. D.; Wai-Keung, C.; Anna, V. D.; Lai-Wah, C. J. Fluorine Chem. 2005, 126, 759-763.
http://dx.doi.org/10.1016/j.jfluchem.2005.02.009

[12]. Kuhler, T. C.; Swanson, M.; Christenson, B.; Klintenberg, A.; Lamm, B.; Fagerhag, J.; Olwegard-Halvarson, M.; Shcherbuchin, V.; Elbrring, T.; Sjstrom, J. J. Med. Chem. 2002, 45, 4282-4299.
http://dx.doi.org/10.1021/jm0208673

[13]. Omar, M. T. Egypt. J. Pharm. Sci. 1997, 38, 281-289.

[14]. Hopkins, K. T.; Wilson, W. D; Bender, B. C; Mc-Curdy, D. R; Boykin, D. W. J. Med. Chem. 1998, 41, 3872-3878.
http://dx.doi.org/10.1021/jm980230c
PMid:9748362

[15]. Dax, S. L. Antibacterial chemotherapeutic agents, Chapman & Hall, 1997, London, UK.

[16]. Cai, L.; Koropatnick, J.; Cherrian, M. G. Chem. Biol. Interact. 2001, 137, 75-88.
http://dx.doi.org/10.1016/S0009-2797(01)00210-1

[17]. Casal, H. H.; Smyth, R. D.; Weissbach, H.; Toohey, J. I.; Ladd, J. N.; Volcani, B. E. J. Biol Chem. 1960, 235, 480-488.

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