European Journal of Chemistry 2013, 4(2), 92-97. doi:10.5155/eurjchem.4.2.92-97.615

Synthesis of some novel 1,2,4-triazole derivatives as potential antimicrobial agents


Mohamed Sayed Behalo (1,*) , Aly Abdelmaboud Aly (2) , Ashraf Farouk Wasfy (3) , Marwa Mohamed Rizk (4)

(1) Chemistry Department, Faculty of Science, Benha University, Benha, 13518, Egypt
(2) Chemistry Department, Faculty of Science, Benha University, Benha, 13518, Egypt
(3) Chemistry Department, Faculty of Science, Benha University, Benha, 13518, Egypt
(4) Chemistry Department, Faculty of Science, Benha University, Benha, 13518, Egypt
(*) Corresponding Author

Received: 18 Apr 2012, Accepted: 05 Jun 2012, Published: 30 Jun 2013

Abstract


An efficient synthesis of 1,2,4-triazole derivatives, fused to five and six membered rings from 4-amino-5-[(quinolin-8-yloxy)methyl]-4H-1,2,4-triazole-3-thiole (2) was described. The structural formula of all derivatives was confirmed and characterized by elemental analysis and spectral studies. Some of the synthesized compounds were also investigated for their antibacterial and antifungal activities and compared with standard drugs. Most of the tested compounds demonstrated potent to weak antimicrobial activities.

4_2_92_97

Keywords


Quinoline; 1,2,4-Triazole; Spectroscopy; Antifungal activities; Antibacterial activities; 1,2,4-Triazolo[3,4-b]thiadiazole

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DOI: 10.5155/eurjchem.4.2.92-97.615

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How to cite


Behalo, M.; Aly, A.; Wasfy, A.; Rizk, M. Eur. J. Chem. 2013, 4(2), 92-97. doi:10.5155/eurjchem.4.2.92-97.615
Behalo, M.; Aly, A.; Wasfy, A.; Rizk, M. Synthesis of some novel 1,2,4-triazole derivatives as potential antimicrobial agents. Eur. J. Chem. 2013, 4(2), 92-97. doi:10.5155/eurjchem.4.2.92-97.615
Behalo, M., Aly, A., Wasfy, A., & Rizk, M. (2013). Synthesis of some novel 1,2,4-triazole derivatives as potential antimicrobial agents. European Journal of Chemistry, 4(2), 92-97. doi:10.5155/eurjchem.4.2.92-97.615
Behalo, Mohamed, Aly Abdelmaboud Aly, Ashraf Farouk Wasfy, & Marwa Mohamed Rizk. "Synthesis of some novel 1,2,4-triazole derivatives as potential antimicrobial agents." European Journal of Chemistry [Online], 4.2 (2013): 92-97. Web. 21 Oct. 2019
Behalo, Mohamed, Aly, Aly, Wasfy, Ashraf, AND Rizk, Marwa. "Synthesis of some novel 1,2,4-triazole derivatives as potential antimicrobial agents" European Journal of Chemistry [Online], Volume 4 Number 2 (30 June 2013)

DOI Link: https://doi.org/10.5155/eurjchem.4.2.92-97.615

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