European Journal of Chemistry 2010, 1(4), 322-324. doi:10.5155/eurjchem.1.4.322-324.65

Synthesis of some pyridyl and cyclohexyl substituted 1,2,4 triazole, 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives


Sattar Ebrahimi (1,*)

(1) Department of Chemistry, Islamic Azad University, Malayer Branch, IR-65718-117, Iran
(*) Corresponding Author

Received: 16 Apr 2010, Accepted: 26 Sep 2010, Published: 22 Dec 2010

Abstract


New 1,2,4-triazoles (4a-c), 1,3,4-thiadiazoles (5a-c) and 1,3,4-oxadiazoles (6a-c) containing isomeric pyridyl and cyclohexyl were synthesized by intramolecular cyclization of 1,4-disubstituted thiosemicarbazides (3a-c) in alkaline media, acid and neutral condition respectively. The chemical structures of newly synthesized compounds were established with help of FT-IR, 1H-NMR and mass spectral data.

1_4_322_324_800


Keywords


1,2,4-Triazole; 1,3,4-Thiadiazole; 1,3,4-Oxadiazole; Thiosemicarbazide

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DOI: 10.5155/eurjchem.1.4.322-324.65

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Citations

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[1]. Hossein Pasha Ebrahimi, Jabbar S. Hadi, Tahseen A. Alsalim, Thaer S. Ghali, Zeinab Bolandnazar
A novel series of thiosemicarbazone drugs: From synthesis to structure
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy  137, 1067, 2015
DOI: 10.1016/j.saa.2014.08.146
/


[2]. Mashooq Ahmad Bhat, Mohamed A. Al-Omar, Ahmed M. Naglah, Mohamed M. Abdulla, Hoong-Kun Fun
Synthesis and antitumor activity of 4-cyclohexyl/aryl-5-(pyridin-4-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones
Medicinal Chemistry Research  24(4), 1558, 2015
DOI: 10.1007/s00044-014-1216-5
/


References

[1]. Suresh Kumar, G. V.; Rajendraprasad, Y.; Mallikarjuna, B. P.; Chandrashekar, S. M.; Kistayya, C. Eur. J. Med. Chem. 2010, 45, 2063-2074.
doi:10.1016/j.ejmech.2010.01.045
PMid:20149496

[2]. Mallikarjuna, B. P.; Sastry, B. S.; Suresh Kumar, G. V.; Rajendraprasad, Y.; Chandrashekar, S. M.; Sathisha, K. Eur. J. Med. Chem. 2009, 44, 4739-4746.
doi:10.1016/j.ejmech.2009.06.008
PMid:19589626

[3]. Onkol, T.; Cakir, B.; Sahin, M. F. Turk. J. Chem. 2004, 28, 461-466.

[4]. Schenone, S.; Bruno, O.; Ranise, A.; Bondavalli, F.; Filippeli, W.; Falcone, G.; Giordano, L.; Vitelli, M. R. Bioorg. Med. Chem. 2001, 9, 2149-2153.
doi:10.1016/S0968-0896(01)00121-3

[5]. Holla, B. S.; Gonsalves, R.; Shenoy, S. Eur. J. Med. Chem. 2000, 35, 267– 271.
doi:10.1016/S0223-5234(00)00154-9

[6]. Gokce. M.; Cakir, B.; Erol, K.; Sahin, M. F. Arch. Pharm. 2001, 334, 279-283.

[7]. Laddi, U. V.; Desai, S. R.; Bennur, R. S.; Bennur, S. C. Ind. J. Heterocycl. Chem. 2002, 11, 319–322.

[8]. Sahin, G.; Palaska, E.; Melike Ekizoglu, O. M. Il Farmaco 2002, 57, 539–545.
doi:10.1016/S0014-827X(02)01245-4

[9]. Li, Z.; Gu, Z.; Yin, K.; Zhang, R.; Deng, Q.; Xiang, J. Eur. J. Med. Chem. 2009, 44, 4716-4720.
doi:10.1016/j.ejmech.2009.05.030
PMid:19560842

[10]. Ali, T. A.; El-Kazak, A. M. Eur. J. Chem. 2010, 1(1), 6-11.
doi:10.5155/eurjchem.1.1.6-11.12

[11]. Rollas, S.; Kalyoncuoğlu, N.; Sür-Altiner, D.; Yegenoğlu, Y. Pharmazie 1993, 48, 308-309.
PMid:8321884

[12]. Holla, B. S.; Rao, B. S.; Sarojini, B. K.; Akberali, P. M. Eur. J. Med. Chem. 2004, 39, 777-783.
doi:10.1016/j.ejmech.2004.06.001
PMid:15337290

[13]. Duran, A.; Dogan, H. N.; Rollas S.; Farmaco 2002, 57, 559-564.
doi:10.1016/S0014-827X(02)01248-X

[14]. Sadana, A. K.; Mirza, Y.; Aneja, K. R.; Prakash, O. Eur. J. Med. Chem. 2003, 38, 533-538.
doi:10.1016/S0223-5234(03)00061-8

[15]. Vu, C. B.; Shields, P.; Peng, B.; Kumaravel, G.; Jin, X.; Phadke, D.; Wang, J.; Engber, T.; Ayyub, E.; Petter, R. Bioorg. Med. Chem. Lett. 2004, 14, 4835-838.
doi:10.1016/j.bmcl.2004.07.048

[16]. Ilango, K.; Valentina, P. Eur. J. Chem. 2010, 1(1), 50-53.
doi:10.5155/eurjchem.1.1.50-53.4

[17]. Foroughifar, N.; Mobinikhaledi, A.; Ebrahimi, S. Synthesis 2009, 15, 2557-2560.
doi:10.1055/s-0029-1217398

[18]. Mobinikhaledi, A.; Foroughifar, N.; Khanpour, M.; Ebrahimi, S. Eur. J. Chem. 2010, 1(1), 33-36.
doi:10.5155/eurjchem.1.1.33-36.5

[19]. Foroughifar, N.; Mobinikhaledi, A.; Ebrahimi, S.; Moghanian, H.; Bodaghi Fard, M. A.; Kalhor, M. Tetrahedron Lett. 2009, 50, 836-839.
doi:10.1016/j.tetlet.2008.12.014

[20]. Foroughifar, N.; Mobinikhaledi, A.; Ebrahimi, S.; Bodaghi Fard, M. A.; Moghanian, M. J. Chin. Chem. Soc. 2009, 56, 1043-1047.

[21]. Foroughifar, N.; Mobinikhaledi, A.; Ebrahimi, S. Synthetic Commun. 2010, 40, 2421-2428.
doi:10.1080/00397910903261387

[22]. Zamani, Kh.; Faghihi, Kh.; Tofighi, T. Turk. J. Chem. 2004, 28, 95-100.


How to cite


Ebrahimi, S. Eur. J. Chem. 2010, 1(4), 322-324. doi:10.5155/eurjchem.1.4.322-324.65
Ebrahimi, S. Synthesis of some pyridyl and cyclohexyl substituted 1,2,4 triazole, 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives. Eur. J. Chem. 2010, 1(4), 322-324. doi:10.5155/eurjchem.1.4.322-324.65
Ebrahimi, S. (2010). Synthesis of some pyridyl and cyclohexyl substituted 1,2,4 triazole, 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives. European Journal of Chemistry, 1(4), 322-324. doi:10.5155/eurjchem.1.4.322-324.65
Ebrahimi, Sattar. "Synthesis of some pyridyl and cyclohexyl substituted 1,2,4 triazole, 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives." European Journal of Chemistry [Online], 1.4 (2010): 322-324. Web. 20 Jan. 2019
Ebrahimi, Sattar. "Synthesis of some pyridyl and cyclohexyl substituted 1,2,4 triazole, 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives" European Journal of Chemistry [Online], Volume 1 Number 4 (22 December 2010)

DOI Link: https://doi.org/10.5155/eurjchem.1.4.322-324.65

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