European Journal of Chemistry 2012, 3(4), 437-441. doi:10.5155/eurjchem.3.4.437-441.677

Synthesis and antimicrobial evaluation of some new quinazolin-4(3H)-one derivatives


Naglaa Fawzy (1) , Madeha Othman Ibrahim Ghobashy (2) , Ahmed Kamel El-Ziaty (3,*)

(1) Chemistry Department, Faculty of Science Ain Shams University, Abbassia, Cairo, 11566, Egypt
(2) Microbiology Department, Faculty of Science Ain Shams University, Abbassia, Cairo, 11566, Egypt
(3) Chemistry Department, Faculty of Science Ain Shams University, Abbassia, Cairo, 11566, Egypt
(*) Corresponding Author

Received: 11 Sep 2012, Accepted: 20 Sep 2012, Published: 31 Dec 2012

Abstract


The oxazolone derivative 1 was synthesized and converted into a hitherto 3,1-benzoxazin-4-one derivative, 3. A series of quinazolin-4-one derivatives 4a-c and 7-11, as well as quinolinone-3-carboxylic acid derivative, 6, and the amide derivatives, 5a,b, were also synthesized via the 3,1-benzoxazin-4-one derivative. The antimicrobial activity of some of the synthesized compounds was examined against three Gram-positive bacteria (Staphylococcus aureus, Streptococcus mutans and Bacillus subtilis), five Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus mirabilis and Acinetobacter baumannii) and one fungi (Candida albicans), using diffusion method. The results showed that compounds 4a, 7, 10 and 11 exhibited significant antibacterial and antifungal activity comparable to standard drugs.

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Keywords


Oxazolone; Quinazolin-4-one; Triazinoquinazolin; Antimicrobial activity; Imidazoloquinazoline; Quinolinone-3-carboxylic acid

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DOI: 10.5155/eurjchem.3.4.437-441.677

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[1]. Naglaa F. H. Mahmoud, Eman A. El-Bordany, Galal A. Elsayed
Synthesis and Pharmacological Activities of Pyrano[2,3-d]pyrimidine and Pyrano[2,3-d]pyrimidine-5-one Derivatives as New Fused Heterocyclic Systems
Journal of Chemistry  2017, 1, 2017
DOI: 10.1155/2017/5373049
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How to cite


Fawzy, N.; Ghobashy, M.; El-Ziaty, A. Eur. J. Chem. 2012, 3(4), 437-441. doi:10.5155/eurjchem.3.4.437-441.677
Fawzy, N.; Ghobashy, M.; El-Ziaty, A. Synthesis and antimicrobial evaluation of some new quinazolin-4(3H)-one derivatives. Eur. J. Chem. 2012, 3(4), 437-441. doi:10.5155/eurjchem.3.4.437-441.677
Fawzy, N., Ghobashy, M., & El-Ziaty, A. (2012). Synthesis and antimicrobial evaluation of some new quinazolin-4(3H)-one derivatives. European Journal of Chemistry, 3(4), 437-441. doi:10.5155/eurjchem.3.4.437-441.677
Fawzy, Naglaa, Madeha Othman Ibrahim Ghobashy, & Ahmed Kamel El-Ziaty. "Synthesis and antimicrobial evaluation of some new quinazolin-4(3H)-one derivatives." European Journal of Chemistry [Online], 3.4 (2012): 437-441. Web. 14 Nov. 2018
Fawzy, Naglaa, Ghobashy, Madeha, AND El-Ziaty, Ahmed. "Synthesis and antimicrobial evaluation of some new quinazolin-4(3H)-one derivatives" European Journal of Chemistry [Online], Volume 3 Number 4 (31 December 2012)

DOI Link: https://doi.org/10.5155/eurjchem.3.4.437-441.677

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