European Journal of Chemistry

One-pot multi-component synthesis of tetrahydroquinazolinones via Biginelli condensation using molecular iodine as a catalyst



Main Article Content

Mohsen Abdel-Motaal Gomaa
Abdel-Wahed Rashad Sayed
Ragab Ali Masoud

Abstract

Tetrahydroquinazolinone derivatives were synthesized in moderate to high yields via one‐pot three component Biginelli reaction of dimedone, urea or thiourea and corresponding aromatic aldehydes in the presence of molecular iodine as an efficient catalyst, in ethanol under reflux conditions. This protocol offers several advantages including good yields of products and easy experimental work‐up procedure.

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Gomaa, M. A.-M.; Sayed, A.-W. R.; Masoud, R. A. One-Pot Multi-Component Synthesis of Tetrahydroquinazolinones via Biginelli Condensation Using Molecular Iodine As a Catalyst. Eur. J. Chem. 2013, 4, 459-461.

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