European Journal of Chemistry 2014, 5(1), 96-100 | doi: https://doi.org/10.5155/eurjchem.5.1.96-100.865 | Get rights and content






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Spectrophotometric methods for the simultaneous determination of paracetamol and dantrolene sodium in pharmaceutical dosage form


Ramzia Ismail El-Bagary (1) , Ehab Farouk Elkady (2) , Marwa Ahmed Hegazi (3,*) , Nour Eldin Amin (4)

(1) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
(2) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
(3) Drug Radiation Research Department, National Centre for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo 11787, Egypt
(4) Drug Radiation Research Department, National Centre for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo 11787, Egypt
(*) Corresponding Author

Received: 03 Jul 2013 | Revised: 23 Aug 2013 | Accepted: 21 Sep 2013 | Published: 31 Mar 2014 | Issue Date: March 2014

Abstract


Accurate, precise and simple spectrophotometric methods have been developed and validated for the determination of paracetamol (PAR) and dantrolene sodium (DAS). Spectrophotometric methods including zero order, first derivative (1D) and derivative ratio methods (1DD) have been developed. The zero order spectrophotometric method was used for the determination of DAS in the range of 1-20 μg/mL by measuring the absorbance at 379 nm where PAR exhibits zero reading. 1D and 1DD methods were used for the determination of PAR in the range of 1.5-20.0 μg/mL by measuring the peaks amplitudes at 265.5 nm and 265.0 nm, respectively. The proposed methods were used to determine PAR in binary mixture with DAS in the laboratory prepared mixtures and in pharmaceutical dosage form. The results obtained were statistically evaluated and found to be accurate and precise and can be satisfactorily applied for the quality control analysis of the cited drugs.


Keywords


Dosage form; Paracetamol; Dantrolene sodium; First derivative ratio; Spectrophotometric method; Simultaneous determination

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DOI: 10.5155/eurjchem.5.1.96-100.865

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Citations

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[1]. Eglal A. Abdelaleem, Ibrahim A. Naguib, Eman S. Hassan, Nouruddin W. Ali
Development and Validation of Three Spectrophotometric Methods for Simultaneous Determination of Paracetamol and Pamabrom in Bulk and Pharmaceutical Formulation
Analytical Chemistry Letters  6(1), 13, 2016
DOI: 10.1080/22297928.2016.1138882
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[2]. Hesham Salem, Dalia Mohamed
A comparative study of smart spectrophotometric methods for simultaneous determination of a skeletal muscle relaxant and an analgesic in combined dosage form
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy  140, 166, 2015
DOI: 10.1016/j.saa.2014.12.099
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[3]. Nada S. Abdelwahab, Maha M. Abdelrahman, John M. Boshra, Ahmed A. Taha
Different stability‐indicating chromatographic methods for specific determination of paracetamol, dantrolene sodium, their toxic impurities and degradation products
Biomedical Chromatography  33(9), , 2019
DOI: 10.1002/bmc.4598
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How to cite


El-Bagary, R.; Elkady, E.; Hegazi, M.; Amin, N. Eur. J. Chem. 2014, 5(1), 96-100. doi:10.5155/eurjchem.5.1.96-100.865
El-Bagary, R.; Elkady, E.; Hegazi, M.; Amin, N. Spectrophotometric methods for the simultaneous determination of paracetamol and dantrolene sodium in pharmaceutical dosage form. Eur. J. Chem. 2014, 5(1), 96-100. doi:10.5155/eurjchem.5.1.96-100.865
El-Bagary, R., Elkady, E., Hegazi, M., & Amin, N. (2014). Spectrophotometric methods for the simultaneous determination of paracetamol and dantrolene sodium in pharmaceutical dosage form. European Journal of Chemistry, 5(1), 96-100. doi:10.5155/eurjchem.5.1.96-100.865
El-Bagary, Ramzia, Ehab Farouk Elkady, Marwa Ahmed Hegazi, & Nour Eldin Amin. "Spectrophotometric methods for the simultaneous determination of paracetamol and dantrolene sodium in pharmaceutical dosage form." European Journal of Chemistry [Online], 5.1 (2014): 96-100. Web. 5 Aug. 2020
El-Bagary, Ramzia, Elkady, Ehab, Hegazi, Marwa, AND Amin, Nour. "Spectrophotometric methods for the simultaneous determination of paracetamol and dantrolene sodium in pharmaceutical dosage form" European Journal of Chemistry [Online], Volume 5 Number 1 (31 March 2014)

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DOI Link: https://doi.org/10.5155/eurjchem.5.1.96-100.865

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