European Journal of Chemistry

Synthesis, reactions and biological evaluation of some novel thienothiophene derivatives

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Published: Sep 30, 2019
DOI: https://doi.org/10.5155/eurjchem.10.3.209-217.1850
Keywords:
Chalcone, Isoxazole, Diazepine, Oxazepine, Thienothiophene, Antibacterial activity
Section
Research Article
Issue
Vol. 10 No. 3 (2019): September 2019
Dates
Received 2019-03-18
Accepted 2019-04-06
Published 2019-09-30
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Main Article Content

Mounir Abbas Ali Mohamed
Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt
http://orcid.org/0000-0001-7080-8505
Hanan Salah
Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt
http://orcid.org/0000-0003-3645-0874
Ahmed Mohamed Mohamed El-Saghier
Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt
http://orcid.org/0000-0002-4338-1486

Abstract

Synthesis of some new bis(chalcones)-based thienothiophene derivatives and study of their synthetic utilities as building blocks for new bis(thiazole), bis(dihydropyran), bis(dihydro pyridine), bis(isoxazoles), bis(pyrazoles), bis(hydropyrimidinethiones), bis(tetrahydro diazepines, oxazepines) and bis(dihydrobenzodiazepnies, benzoxazepines) each linked to a thienothiophene core, is reported. Biological evaluation of the obtained compounds as antibacterial agents was achieved. Compounds 4b, 4c, 7a, 6a, 9a and 11b were found to be very potent against P. aeruginosa, E. coli and K. pneumonia.


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Mohamed, M. A. A.; Salah, H.; El-Saghier, A. M. M. Synthesis, Reactions and Biological Evaluation of Some Novel Thienothiophene Derivatives. Eur. J. Chem. 2019, 10, 209-217.

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