European Journal of Chemistry 2012, 3(3), 332-336 | doi: https://doi.org/10.5155/eurjchem.3.3.332-336.637 | Get rights and content

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Conductometric titration method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl using silver nitrate


Magda Mohamed Ayad (1) , Hisham Ezzat Abdellatef (2) , Mervat Mohamed Hosny (3,*) , Yassmin Ahmed Sharaf (4)

(1) Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
(2) Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
(3) Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
(4) Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
(*) Corresponding Author

Received: 15 May 2012 | Accepted: 10 Jul 2012 | Published: 30 Sep 2012 | Issue Date: September 2012

Abstract


A simple, precise, rapid, and low-cost conductometric method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl in pure form and in pharmaceutical formulations using silver nitrate has been described. The method is based on the precipitation of oxalate or chloride ions coming from the cited drugs with silver ions, yielding silver oxalate or silver chloride and the conductance of the solution is measured as a function of the volume of titrant. The studied drugs were evaluated in double distilled water in the range of 1-15 mg. Various experimental conditions were established and results obtained showed good recoveries with relative standard deviation of 0.909, 0.955 and 0.983 for naftidrofuryl, propafenone and sotalol, respectively. The proposed procedures were applied successfully to the analysis of these drugs in their pharmaceutical formulations. Results were favorably comparable to the official or reference methods.

3_3_332_336_800


Keywords


Oxalate; Sotalol HCl; Silver nitrate; Propafenone HCl; Naftidrofuryl oxalate; Conductometric titration

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DOI: 10.5155/eurjchem.3.3.332-336.637

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Citations

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[2]. Xu-Zhi Zhang, Meng-Shi Huang, Qian-Qian Yang, Dong-Sheng Ding, Jun Zhao, Wen-Rong Yang, Ke-Ming Qu
Simple and cost-effective determination of ciprofloxacin hydrochloride by electrical micro-titration
Chinese Chemical Letters  28(7), 1406, 2017
DOI: 10.1016/j.cclet.2017.03.019
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[3]. Afaf A. Abdelmonem, Gamal H. Ragab, Hisham A. Hashem, Eman A. Bahgat
A fast stability-indicating HPLC method for determination of sotalol hydrochloride in bulk powder and in dosage form
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DOI: 10.3233/MGC-150200
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[4]. Mohammed Al- Bratty, Hatim Murayzin, Adel Almanaa, Mohammed Qasem Tawhari, Zia Ur Rehman, Hassan A. Alhazmi, Sadique Akhtar Javed, Md Shamsher Alam
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DOI: 10.13005/ojc/350518
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[5]. Hassan A. Alhazmi, AbdulRhman Ali Bokar Nasib, Yasser Ali Musleh, Khaled Qassim Hijri, Zia ur Rehman, Gulrana Khuwaja, Mohammed Al-Bratty, Sadique A. Javed, Ismail A. Arbab
Application of drug–metal ion interaction principle in conductometric determination of imatinib, sorafenib, gefitinib and bosutinib
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DOI: 10.1515/chem-2020-0123
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How to cite


Ayad, M.; Abdellatef, H.; Hosny, M.; Sharaf, Y. Eur. J. Chem. 2012, 3(3), 332-336. doi:10.5155/eurjchem.3.3.332-336.637
Ayad, M.; Abdellatef, H.; Hosny, M.; Sharaf, Y. Conductometric titration method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl using silver nitrate. Eur. J. Chem. 2012, 3(3), 332-336. doi:10.5155/eurjchem.3.3.332-336.637
Ayad, M., Abdellatef, H., Hosny, M., & Sharaf, Y. (2012). Conductometric titration method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl using silver nitrate. European Journal of Chemistry, 3(3), 332-336. doi:10.5155/eurjchem.3.3.332-336.637
Ayad, Magda, Hisham Ezzat Abdellatef, Mervat Mohamed Hosny, & Yassmin Ahmed Sharaf. "Conductometric titration method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl using silver nitrate." European Journal of Chemistry [Online], 3.3 (2012): 332-336. Web. 15 Jan. 2021
Ayad, Magda, Abdellatef, Hisham, Hosny, Mervat, AND Sharaf, Yassmin. "Conductometric titration method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl using silver nitrate" European Journal of Chemistry [Online], Volume 3 Number 3 (30 September 2012)

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