European Journal of Chemistry

IL-17 level in patients with acute myocardial infarction and its effect on lipid profile



Main Article Content

Ammal Esmaeel Ibrahim
Hiba Ali Hasan
Alaa Hussein Jawad

Abstract

Myocardial infarction (MI) is considered as the major cause of death and disability worldwide, and despite considerable advances in diagnosis and treatment, continues to be a major public health problem. Interleukin-17 (IL-17) is leukocyte-derived cytokine with effects especially on epithelial cells in various tissues. This study designed to investigate the level of IL-17 and its effect on lipid profile in patients with Acute Myocardial Infarction. The study included 50 patients with acute myocardial infarction forty healthy subjects as control group. The levels of IL-17 were significantly elevated in all patients groups (p < 0.001), total cholesterol, LDL, VLDL were significantly elevated (p < 0.001) in all patients as well.  There was positive correlation between IL-17 with HDL, while there was negative correlation with total cholesterol and LDL. The results show significant increase in levels of IL-17, in acute myocardial infarction patients. IL-17 positively correlated with HDL and negatively correlated with total cholesterol and LDL, which lead to consider it as cardio protective factor.


icon graph This Abstract was viewed 1226 times | icon graph Article PDF downloaded 650 times

How to Cite
(1)
Ibrahim, A. E.; Hasan, H. A.; Jawad, A. H. IL-17 Level in Patients With Acute Myocardial Infarction and Its Effect on Lipid Profile. Eur. J. Chem. 2014, 5, 186-188.

Article Details

Share
Crossref - Scopus - Google - European PMC
References

[1]. Liu, S.; Song, X.; Chrunyk, B. A.; Shanker, S.; Hoth, L. R.; Marr, E. S.; Griffor, M. C. Nature Commun. 2013, 4, 1888-1888.
http://dx.doi.org/10.1038/ncomms2880

[2]. Zhang, B.; Liu, C.; Qian, W.; Han, Y.; Li, X.; Deng, J. J. Immunol. 2013, 190(5), 2320-2326.
http://dx.doi.org/10.4049/jimmunol.1202922

[3]. Janis, K.; Thomas, J.; Richard, A.; Barbara, A. Kuby Immunology. San Francisco, W. H. Freeman, 2007, pp. 396.

[4]. Chiricozzi, A.; Guttman-Yassky, E.; Suarez-Farinas, M.; Nograles, KE.; Tian, S.; Cardinale, I.; Chimenti, S.; Krueger, J. G. J. Invest. Dermatol. 2011, 131(3), 677-687.
http://dx.doi.org/10.1038/jid.2010.340

[5]. Huang, C. S.; Timothy, R.; Arditi, M. Innate Immun. 2010, 2, 325-333.
http://dx.doi.org/10.1159/000314626

[6]. Hansson, G. K.; Libby, P.; Schonbeck, U.; Yan, Z. Q. Circ. Res. 2002, 9(1), 281-291.
http://dx.doi.org/10.1161/01.RES.0000029784.15893.10

[7]. Hansson, G. K. N. Engl. J. Med. 2005, 352(16), 1685-1695.
http://dx.doi.org/10.1056/NEJMra043430

[8]. O'Connor, W.; Kamanaka, M.; Booth, C. J.; Town, T.; Nakae, S.; Iwakura, Y.; Kolls, J. K.; Flavell, R. A. Nat. Immunol. 2009, 10, 603-609.
http://dx.doi.org/10.1038/ni.1736

[9]. Butcher, M.; Galkina, E. Thromb. Haemost. 2011, 106, 787-795.
http://dx.doi.org/10.1160/TH11-05-0342

[10]. Smith, E.; Konkal-Matt, R.; Prasad, M. B.; AncaDobrian, J. K.; Kolls, K. L.; Elena, G. Circulation 2010, 121(15), 1746-1755.

[11]. Sergejeva, S.; Ivanov, S.; Lotvall, J.; Linden A. J. Respir. Cell. Mol. Biol. 2005, 33, 248-253.
http://dx.doi.org/10.1165/rcmb.2004-0213OC

[12]. Rao, D. A.; Eid, R. E.; Qin, L.; Yi, T.; Kirkiles-Smith, N. C.; Tellides, G.; Pober, J. S. J. Exp. Med. 2008, 205, 3145-3158.
http://dx.doi.org/10.1084/jem.20081661

[13]. Mohsen, I. M. Obes. Rev. 2010, 11, 11-18.
http://dx.doi.org/10.1111/j.1467-789X.2009.00623.x

[14]. Erbel, C.; Chen, L.; Bea, F.; Wangler, S.; Celik, S.; Lasitschka, F.; Wang, Y.; Bockler, D.; Katus, H. A.; Dengler, T. J. J. Immunol. 2009, 183, 8167-8175.
http://dx.doi.org/10.4049/jimmunol.0901126

[15]. Taleb, S.; Tedgui, A.; Mallat, Z. Curr. Opin. Pharmacol. 2010, 10, 197-202.
http://dx.doi.org/10.1016/j.coph.2010.02.003

[16]. Gao, Q.; Jiang, Y.; Ma, T.; Zhu, F.; Gao, F.; Zhang, P.; Guo, C.; Wang, Q.; Wang, X.; Ma, C.; Zhang, Y.; Chen, W.; Zhang, L. J. Immunol. 2010, 185, 5820-5827.
http://dx.doi.org/10.4049/jimmunol.1000116

[17]. Barry, S. P.; Ounzain, S.; Cormick, J. A.; Scarabelli, T. M.; Chen-Scarabelli, C.; Saravolatz, L. I. I.; Faggian, G.; Mazzucco, A.; Suzuki, H.; Thiemermann, C.; Knight, R. A.; Latchman, D. S.; Stephanou, A. Int. J. Cardiol. 2013, 163, 326-334.
http://dx.doi.org/10.1016/j.ijcard.2011.08.849

[18]. Troitskaya, M.; Baysa, A.; Vaage, J.; Sand, K. L.; Maghazachi, A. A.; Valen, G. Toxins. 2012, 4, 1427-1439.
http://dx.doi.org/10.3390/toxins4121427

[19]. Zuniga, L. A.; Shen, W. J.; Joyce-Shaikh, B.; Pyatnova, E. A.; Richards, A. G.; Thom, C.; Andrade, S. M.; Cua, D. J.; Fredric B. Kraemer, F. B.; Butcher, E. C. J. Immunol. 2010, 185(11), 6947-6959.
http://dx.doi.org/10.4049/jimmunol.1001269

[20]. Nuzhatun, N.; Qazi, M. A. Indian J. Dermatol. Venereol. Leprol. 2010, 76, 662-665.
http://dx.doi.org/10.4103/0378-6323.72462

[21]. Gastro, A. Am. J. Resp. Crit. Care 2010, 182(5), 661-668.
http://dx.doi.org/10.1164/rccm.201001-0007OC

[22]. Canizales-Quinteros, S.; Aguilar-Salinas, C. A.; Reyes-Rodriguez, E.; Riba, L.; Rodriguez-Torres, M.; Ramirez-Jimenez, S.; Huertas-Vazquez, A.; Fragoso-Ontiveros, V.; Zentella-Dehesa, A.; Ventura-Gallegos, J. L.; Vega-Hernandez, G.; Lopez-Estrada, A. Auron-Gomez, M.; Gomez-Perez, F.; Rull, J.; Cox, N. J.; Bell, G. I.; Maria Teresa Tusie-Luna, M. T. Circ. Res. 2003, 92, 569-576.
http://dx.doi.org/10.1161/01.RES.0000064174.69165.66

[23]. Al-Aubaidy, H. A.; Sahib, H. A.; Mohammad, B. I.; Hadi, N. R.; Abas, S. M. J. Pharm. Tech. Drug Res. 2013, 2, 11. DOI: 10. 7243/2050-120X-2-11.

[24]. Smith, E.; Prasad, K. M.; Butcher, M.; Dobrian, A.; Kolls, J. K.; Ley, K.; Galkina, E. Circulation 2010, 121, 1746-1755.
http://dx.doi.org/10.1161/CIRCULATIONAHA.109.924886

[25]. Brull, F.; Mensink, R. P.; Steinbusch, M. F.; Husche, C.; Lutjohann, D.; Wesseling, G.; Plat, J. PLOS One. 2012, 7(10), e46895.
http://dx.doi.org/10.1371/journal.pone.0046895

TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).