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oai:ojs.www.eurjchem.com:article/1 2011-04-05T15:59:16Z eurjchem:ART driver

Synthesis and studying the antitumor activity of novel 5-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazole-2(3H)-thiones Galal, Shadia Ahmed Abdelsamie, Ahmed S. Rodriguez, Mireya L. Kerwin, Sean M. El Diwani, Hoda I. Salicylate Hydrogen bonding DFT-Molecular dynamics Vibrational spectroscopy Relaxation spectroscopy The influence of the incorporation of 1,3,4-oxadiazole ring into 2-methyl-1H-benzimidazole derivatives producing a series of substituted 5(6)-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazoles on the antitumor activity was studied in this study. The antitumor activity of the new compounds was tested against breast cancer cell line MCF-7 and lung cancer cell line A549. S-5-(2-methyl-1H-benzo[d]imidazol-5-yl)-1,3,4-oxadiazol-2-yl 2-nitrobenzenesulfonothioate (9) showed potent activity against both MCF-7 and A549 cell lines. Whereas, compounds 7, 11-13 and 15-17 have moderate growth inhibitory activity on the two cell lines. Atlanta Publishing House LLC 2010-06-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1 10.5155/eurjchem.1.2.67-72.1 European Journal of Chemistry; Vol. 1 No. 2 (2010): June 2010; 67-72 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1/PDF