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oai:ojs.www.eurjchem.com:article/1010 2014-06-30T08:07:08Z eurjchem:ART driver

Computational study and antimicrobial activity of few Dapsone Schiff base derivatives Al-Masoudi, Wasfi Abood Al-Tememy, Tamadher Mohammad Al-Assadi, Rafid Hmedan DFT Dapsone Schiff base Antimicrobial NMR spectroscopy Computational study Condensation of 4,4-diaminodiphenyl sulfone (Dapsone) with aliphatic and aromatic aldehydes yielded a few Schiff base derivatives in good yields. The optimized structural parameters (bond lengths and bond angles) of three azomethine compounds have been obtained by using the GAUSSIAN 09 program package. Conformer of compound 1 has the highest energy, which has less stability than compounds 2 and 3 at the same model. The synthesized compounds were screened for antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus subtilis and fungicidal activity against Aspergillus niger and Candida albicans. All compounds exhibited potent antibacterial and antifungal activity with the reference standard ciprofloxacin and Amphotericin B, respectively. Atlanta Publishing House LLC 2014-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1010 10.5155/eurjchem.5.2.351-355.1010 European Journal of Chemistry; Vol. 5 No. 2 (2014): June 2014; 351-355 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1010/pdf_1010