2026-04-29T13:11:25Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1020 2014-09-30T03:41:50Z eurjchem:ART driver

Synthesis and evaluation of antimitotic activity of new tetralone acid analogues of podophyllotoxin Shivakumar, Santhekasalagere Basavaiah Basavaraju, Yeriyur Basavaiah Umesha, Basavaiah Krishna, Mudeenahally Hucchegowda Mallesha, Ningegowda Ketones Itaconic acids Tetralone acids Antimitotic activity Stobbe condensation Catalytic hydrogenation The new tetralone acids (7a-e) were synthesized as analogues of podophyllotoxin. They were prepared by replacing 3,4,5-trimethoxyphenyl ring with cyclohexyl group in podophyllotoxin and 1,3-methylene dioxy ring with methoxy, hydrogen, methyl, thiomethyl, and fluorine atoms. The analogues of podophyllotoxin were synthesized using Gensler’s method with some changes in reagents and experimental procedure. The structures of the synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, mass spectra and elemental analysis data. The synthesized tetralones acids were screened for their antimitotic activity. It is noteworthy that compound 7b possessed excellent antimitotic activity, 7c and 7e showed considerable activity and remaining 7a and 7d possessed low activity. Atlanta Publishing House LLC 2014-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1020 10.5155/eurjchem.5.3.424-429.1020 European Journal of Chemistry; Vol. 5 No. 3 (2014): September 2014; 424-429 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1020/pdf_1020