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oai:ojs.www.eurjchem.com:article/1040 2014-09-30T03:41:50Z eurjchem:ART driver

Synthesis of new 3,4-dihydropyrano[c]chromene derivatives and their evaluation as acetyl cholinesterase inhibitors Bouazizi, Younes Romdhane, Anis Jannet, Hichem Ben Chromene Iminoethers Pyrrolochromene Pyridinochromene Dihydropyrano[c]chromene Anti-acetylcholinesterase activity 2-Amino-4-phenyl-4,5-dihydro-5-oxopyrano[2,3-c]chromen-3-carbonitrile derivatives (8a-d) have been isolated in good yields by the reaction of corresponding 4-hydroxycoumarin (1) with substituted aldehydes (2a-d) and malononitrile (3) under reflux conditions. The reactivity of α-functionalized iminoethers (9a-d) with hydrazine, hydroxylamine and piperidine was studied. The synthesized compounds were characterized by various techniques including spectroscopy. Compounds 8-11 were also evaluated as potential acetylcholinesterase inhibitors. Atlanta Publishing House LLC 2014-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1040 10.5155/eurjchem.5.3.457-462.1040 European Journal of Chemistry; Vol. 5 No. 3 (2014): September 2014; 457-462 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1040/pdf_1040