2026-05-16T19:19:14Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1073 2014-09-30T03:41:50Z eurjchem:ART driver

Design, synthesis, and biological profile of novel N-(5-aryl-1,3,4-thiadiazol-2-yl) hydrazinecarboxamides El-Behairy, Mohammed Farrag Aboul-Enein, Mohamed Nabil El-Azzouny, Aida Abdel-Sattar Saleh, Ola Ahmed Maklad, Yousreya Aly Aboutabl, Mona Elsayed Maghraby, Amany Sayed ELISA Thiadiazoles Arylthiadiazole Anticonvulsants Immunomodulatory Hydrazinecarboxamides New series of arylthiadiazole hydrazinecarboxamides (5a-e) have been synthesized by hydrazinolysis of carbamates (4a-e) and spectrally characterized. The new candidates have been screened for their anticonvulsant and immunomodulatory activities. Compound 5e was the most potent anticonvulsant candidate as it showed 100% protection against both maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) screens without neurotoxicity at 100 mg/kg (0.318 mmol/kg). With respect to immunomodulation, compounds 5a and 5d revealed immunostimulatory activity while compounds 5b, 5c, and 5e had immunosuppressive responses based on ELISA detection of IgM and IgG levels, counting the total mesenteric lymph nodes lymphocytes, and histo-pathological examinations. Atlanta Publishing House LLC 2014-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1073 10.5155/eurjchem.5.3.488-496.1073 European Journal of Chemistry; Vol. 5 No. 3 (2014): September 2014; 488-496 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1073/pdf_1073