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oai:ojs.www.eurjchem.com:article/1086 2014-09-30T03:41:50Z eurjchem:ART driver

A study of coupling reaction to synthesize diphenylmethane derivatives Bhatti, Huma Aslam Zaheer, Qurat-Ul-Ain Khatoon, Memoona Light, Mark Edward Hameed, Abdul Benzyl alcohol Thionyl chloride Coupling reaction Halogenating agents Phosphorus tribromide Diphenylmethane derivative The class of compounds having diphenylmethane framework occupy a distinct place in natural bioactive compounds and also serve as useful intermediates in various commercially important synthetic molecules. Conventionally, Friedel-Craft type reactions were used to synthesize such diphenylmethane derivatives. However, herein we report a unique approach in which, two benzyl alcohol molecules were coupled in the presence of different halogenating agents (SOCl2, PBr3 and MeSO2Cl) to afford the desired diphenylmethane derivative, bis(2,4-bis(benzyloxy)-5-methoxyphenyl)methane. It has been found that the coupling reaction is strongly influenced by the electronic effects and number of the substituents on the phenyl ring. The resultant compound, bis(2,4-bis(benzyloxy)-5-methoxyphenyl)methane, was obtained in excellent yield (83-85%) and completely characterize with different spectroscopic techniques. Atlanta Publishing House LLC 2014-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/plain https://www.eurjchem.com/index.php/eurjchem/article/view/1086 10.5155/eurjchem.5.3.513-516.1086 European Journal of Chemistry; Vol. 5 No. 3 (2014): September 2014; 513-516 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1086/pdf_1086 https://www.eurjchem.com/index.php/eurjchem/article/view/1086/2564