2026-05-15T23:40:50Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1093 2014-12-31T04:47:25Z eurjchem:ART driver

Synthesis and study of antimicrobial activity of new tetralone esters Hucchegowda, Krishna Mudeenahally Basavaiah, Basavaraju Yeriyur Basavaiah, Umesha Basavaiah, Shivakumar Santhekasalagere Tetralone esters Cyclopropanation Antimicrobial activity Friedel-Crafts acylation Claisen-Schmidt reaction Ethyl monochloro acetate Podophyllotoxin belongs to the class of cyclolignan family of natural products, which exhibits strong antimitotic, anti-AIDS (HIV), antitropical skin disease, antimalarial, virucidal, fungicidal and other biological activities. The new tetralone esters (9a-d) of podophyllotoxin analogues were synthesized in good yields by chalcone route to study their structure-activity relationship. All the products obtained were characterized by spectral and elemental analysis data and they were screened for antimicrobial activity. Compounds 9b and 9c were shown significant antibacterial and antifungal activities. Atlanta Publishing House LLC 2014-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1093 10.5155/eurjchem.5.4.584-587.1093 European Journal of Chemistry; Vol. 5 No. 4 (2014): December 2014; 584-587 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1093/pdf_1093