2026-05-05T18:22:43Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1098 2014-12-31T04:47:25Z eurjchem:ART driver

Synthesis, characterization and in vitro biological evaluation of some new 1,3,5-triazine-chalcone hybrid molecules as Mycobacterium tuberculosis H37Rv inhibitors Dwarampudi, Subbarayal Reddy Dannana, Gowri Sankar Avupati, Vasudeva Rao Bendi, Venkata Satyanarayana Murthy Hybrid molecules Alamar blue assay 1 3 5-Triaizine-chalcone Structure activity relationship Minimum inhibitory concentration Mycobacterium tuberculosis H37Rv A novel series of 1,3,5-triazine-chalcone hybrid molecules (4a-ii) have been synthesized and evaluated in vitro for Mycobacterium tuberculosis H37Rv inhibitory potency using Alamar blue assay and the activity expressed as the minimum inhibitory concentration (MIC) in µg/mL. The antitubercular activity screening data revealed that the compound 4z demonstrated comparatively the most potent inhibitory activity, with MIC value 3.125 µg/mL. It is noteworthy that the compounds 4e, 4p and 4bb also showed appreciable inhibitory activity with MIC value 6.25 µg/mL. Most of the compounds displayed significantly promising activity and their structure-activity relationships were also discussed. This could be the remarkable starting point to develop new lead molecules with potential antitubercular activity. Atlanta Publishing House LLC 2014-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1098 10.5155/eurjchem.5.4.570-576.1098 European Journal of Chemistry; Vol. 5 No. 4 (2014): December 2014; 570-576 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1098/pdf_1098