2026-05-15T23:41:07Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1120 2014-12-31T04:47:25Z eurjchem:ART driver

Synthesis and biological evaluation of new quinazolinone derivatives Asker, Firyal Weli Abbas, Salma Abdul Rudha Al-Bayati, Redha Ibrahim Al-Tamemi, Hanaa Abd Schiff bases Azetidinone Quinazolinone Enzymes activities Antioxidant activity Antimicrobial activity New N-substituted-2-methyl quinazolin-4(3H)-ones derivatives comprising 1,3,4-thiadiazole, Schiff bases and 2-azetidinone moieties are reported. The structures of the newly prepared compounds were confirmed by FT-IR and 1H NMR spectra. The compounds were also evaluated for their antimicrobial, antioxidant and study of inhibition on some enzymes activities. The results suggest that the compounds possess broad spectrum of in-vitro antimicrobial activity. Antioxidant results obtained into the present study indicate that compound 5 show moderate better scavenging activity. Compound 5 demonstrated inhibitory effects on GOT, GPT, GGT and ALP activities, and these effects increase with increasing the concentration of the compound. Atlanta Publishing House LLC 2014-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1120 10.5155/eurjchem.5.4.628-634.1120 European Journal of Chemistry; Vol. 5 No. 4 (2014): December 2014; 628-634 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1120/pdf_1120