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oai:ojs.www.eurjchem.com:article/1147 2015-03-31T07:18:02Z eurjchem:ART driver

Synthesis of some new fluorine substituted thiobarbituric acid derivatives as anti HIV1 and cyclin-dependent kinase 2 (CDK2) for cell tumor division: Part I Al-Harbi, Abdulrahman Salim Abdel-Rahman, Reda Mohammady Asiri, Abdullah Mohamed CDK2 Anti HIV Synthesis Heterocyclic Potential inhibitors Fluorinated thiobarbituric New potential enzyme inhibitors, fluorine-substituted thiobarbituric acid derivatives (2, 3, 9, 8 and 12) and their fused/isolated heterocyclic nitrogen systems (5, 6, 10 and 14) have been obtained from heterocyclization of fluorinated N, Nʹ-disubstituted thiourea (1, 7 and 11) with malonic acid followed by ring closure reactions with primary nitrogen reagents. Structures of the synthesized products have been deduced from their elemental analysis and spectral data. Anti-HIV-1 and inhibition of cyclin-dependent kinase2 (CDK2) for cell tumor division for the synthesized compounds were also evaluated. Atlanta Publishing House LLC 2015-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1147 10.5155/eurjchem.6.1.63-70.1147 European Journal of Chemistry; Vol. 6 No. 1 (2015): March 2015; 63-70 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1147/pdf_1147