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oai:ojs.www.eurjchem.com:article/1148 2015-03-31T07:18:02Z eurjchem:ART driver

Synthesis and characterization of new 3,5-disubstituted-4,5-dihydro-1H-pyrazole and their carbothioamide derivatives Ibrahim, Mohammad Mahmoud Chalcones Pyrazolines Isothiocyanate Carbothioamide Claisen-Schmidt Thiosemicarbazide A new series of substituted pyrazolines (6-10) were synthesized in moderate to excellent yield by treatment of chalcones (1-5) with hydrazine monohydrate. The carbothioamide compounds (11-14) were obtained in 65% to quantitative yield by treatment of chalcones (2, 4, and 5) either with thiosemicarbazide or with phenylisothiocyanate. All new compounds were characterized by various spectroscopic methods such as 1H NMR, 13C NMR, DEPT, COSY, HSQC spectroscopy, elemental analysis, and high resolution mass spectroscopy. The obtained compounds are currently under biological investigations, and the results will be reported elsewhere. Atlanta Publishing House LLC 2015-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1148 10.5155/eurjchem.6.1.78-83.1148 European Journal of Chemistry; Vol. 6 No. 1 (2015): March 2015; 78-83 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1148/pdf_1148