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oai:ojs.www.eurjchem.com:article/116 2011-04-06T05:40:25Z eurjchem:ART driver

Determination of voglibose in pharmaceutical formulations by high performance liquid chromatography using refractive index detection Lakshmi, Karunanidhi Rajesh, Tirumala Voglibose HPLC RID Validation Pharmaceutical formulations Voglibose is a potent glucosidase inhibitor used for type II diabetes mellitus. A simple and rapid high performance liquid chromatographic method with refractive index detection was developed for the determination of voglibose in pharmaceutical formulations. Development was performed on a C18 (250 x 4.6 mm, 5 µ) column using a mobile phase mixture of acetonitrile and water in the ratio of 50:50 which was fixed at a flow rate of 0.5 mL/min. Polarity of voglibose was found to be positive and elution time was found to be less than 5 min. The method was also validated as per ICH guidelines for its linearity, precision, accuracy and robustness. The limit of detection and quantification (LOD and LOQ) were found to be 2.91 and 9.7 µg/mL. The method could be successfully applied for the quantification of voglibose in pharmaceutical formulations. Atlanta Publishing House LLC 2010-12-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/116 10.5155/eurjchem.1.4.262-265.116 European Journal of Chemistry; Vol. 1 No. 4 (2010): December 2010; 262-265 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/116/PDF