2026-05-07T10:45:18Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1172 2015-06-30T08:25:37Z eurjchem:ART driver

Synthesis, characterization, DNA-binding and biological activity of Zn(II) complexes of sulfadiazine with different amino acids El-Henawy, Ahmed Abdlmonem Hanafy, Ahmed Imam Docking Antifungal Amino acid Sulfadiazine DNA-binding Antibacterial activity New Zn(II) complexes (ZnII-VS, ZnII-LS, ZnII-SS, ZnII-CS and ZnII-MS) of the sulfonamide antibiotic sulfadiazine with different amino acids were prepared and fully characterized by elemental analyses, thermal analysis and IR, UV/Vis and 1H NMR spectroscopy. The IR and 1H NMR spectral data show that the ligands behave in a dibasic bidentate fashion coordinating to zinc ion. Interactions of these complexes with DNA were investigated by spectrophotometric method. Moreover, the antibacterial and antifungal activities were evaluated for five ligands and their complexes. The computational study for prediction of absorption, distribution, metabolism, elimination and toxic factors (ADMET) properties were performed for the prepared ligands. Atlanta Publishing House LLC 2015-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1172 10.5155/eurjchem.6.2.117-126.1172 European Journal of Chemistry; Vol. 6 No. 2 (2015): June 2015; 117-126 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1172/pdf_1172