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oai:ojs.www.eurjchem.com:article/1175 2015-06-30T08:25:37Z eurjchem:ART driver

Synthesis, antimicrobial activity and molecular modeling study of some new pyrimidine derivatives Al-Masoudi, Wasfi Abood Mohmmed, Abeer Laily Abass, Wamedh Hashim Al-Masoudi, Najim Aboud 2D NMR Antibiotics Pyrimidine Schiff’s bases Antimicrobial activity Molecular modeling study Condensation of 2-amino-4-chloro-6-methoxypyrimidine with aromatic aldehydes (2-hydroxy-1-naphthaldehyde, 3,4-dihydroxybenzaldehyde and piperonal) afforded products in good yields. The synthesized compounds (Schiff base of pyrimidine derivatives) were screened for their antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Klebsille, Pseudomonas aeruginosa and Salmonella. Additionally, the compounds were tested for antifungicidal activity against Candida albicans, Candida tropicalis and Aspergillus fumigatus. All compounds exhibited potent antibacterial and antifungal activity. Molecular modeling studies were performed, showing the hydrogen bindings and hydrophobic interactions. Atlanta Publishing House LLC 2015-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1175 10.5155/eurjchem.6.2.127-130.1175 European Journal of Chemistry; Vol. 6 No. 2 (2015): June 2015; 127-130 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1175/pdf_1175