2026-05-17T06:31:34Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1219 2015-06-30T08:25:37Z eurjchem:ART driver

Design, synthesis, antimicrobial activity and anticancer screening of some new 1,3-thiazolidin-4-ones derivatives Shehab, Wesam Saber Mouneir, Samar Mohamed Anticancer Schiff’s bases 3-Acetylindol Antimicrobial 1 3-Thiazolidin-4-ones Thiazolopyridine derivatives A series of new thiazolidin-4-ones have been synthesized by the reaction of 3-acetylindole with thiourea to yield 2-amino-arylthiazole (1) which, reacted with 2-chloroacetyl chloride to produce 2-chloroacetamido-4-arylthiazoles (2). The later was treated with potassium thiocyanate to afford the related 2-amino-3-(4-arylthiazol-2-yl) thiazolidin-4-ones (3). Condensation of compounds 1 and 3 with different aromatic aldehydes give Schiff’s bases (4a-c) and (5a-c) reaction of compound 5a-c with thioglycollic acids furnishes the target thiazolidin-4-one molecules (6a-c). Further, condensation of compound 6a with benzaldehyde affords benzylidenethiazolo derivative (7) which on refluxing with malononitrile, acetylacetone afforded thiazolopyridine derivatives (8,9). Structure elucidation of the products has been accomplished on the basis of elemental analysis, IR, 1H NMR data. Compound 3exhibited the most potent antibacterial and anticancer activity. Atlanta Publishing House LLC 2015-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1219 10.5155/eurjchem.6.2.157-162.1219 European Journal of Chemistry; Vol. 6 No. 2 (2015): June 2015; 157-162 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1219/pdf_1219