2026-05-16T01:32:50Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1224 2015-07-26T11:38:34Z eurjchem:ART driver

Synthesis of novel cyanoacetamides derivatives and their urease inhibition studies Rauf, Abdul Nazish, Khalil Ahmed Nasim, Faiz-ul Hassan Yaqoob, Asma Qureshi, Ashfaq Mahmood Furan Thiophene Cyanoactamides Urease inhibition activity Knoevenagel condensation N N-Dimethyl barbituric acid The present study reports a convenient approach for the synthesis of cyanoacetamide based derivatives (7-27) via two-step process involving Knoevenagel reaction, followed by three component reaction to avail desired compounds. All the synthesized compounds were obtained in good to excellent yield and extensively characterized employing 1H NMR, 13C NMR, mass spectrometry and physical parameters. Further, these compounds were screened for urease inhibition. All of the synthesized compounds exhibited good to excellent urease activity notably compound 15 and 19 showed excellent urease inhibition activity with IC50 value ~17.34 μg/mL and 36.75 μg/mL in comparison to thiourea (used as standard) having IC50 value ~27.5 μg/mL. Atlanta Publishing House LLC 2015-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1224 10.5155/eurjchem.6.2.163-168.1224 European Journal of Chemistry; Vol. 6 No. 2 (2015): June 2015; 163-168 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1224/pdf_1224