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oai:ojs.www.eurjchem.com:article/1234 2015-06-30T08:25:37Z eurjchem:ART driver

Determination of metformin hydrochloride in human plasma by UPLC/MS/MS: Application in bioequivalence study Mohammed, Samah Abd Elsabour El-Dardiri, Mohammed Elhabak, Mona Ahmed Abu Zaid, Khaled Ibrahim Plasma Validation UPLC/MS/MS Bioequivalence Chlorpheneramine Metformin hydrochloride Metformin hydrochloride was quantified in human plasma by Ultra Performance Liquid Chromatography with Tandem Mass spectrometric determination (UPLC-MS/MS). The mobile phase used was (Water + 0.1% Formic acid) and (Acetonitrile + 0.1% Formic acid) in the ratio of 80:20 (v:v). An Acquity UPLC HSS T3 1.8 um 2.1×50 mm column was used. The detection was performed on a mass spectrometer (ESI+) using chlorpheniramine as an internal standard. The method was fully validated and it was applied to bioequivalence study of metformin hydrochloride in two brands of the drug with relative bioequivalence of 94.7%. Atlanta Publishing House LLC 2015-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1234 10.5155/eurjchem.6.2.178-182.1234 European Journal of Chemistry; Vol. 6 No. 2 (2015): June 2015; 178-182 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1234/pdf_1234