2026-04-29T05:01:01Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1254 2015-12-31T11:02:45Z eurjchem:ART driver

Synthesis, antimicrobial activity, computational and modeling studies of some new organotellurium compounds containing azo moities Al-Masoudi, Wasfi Aboud Al-Asadi, Rafid Hmedan Othman, Rasha Munther Al‐Masoudi, Najim Aboud LANL2DZ Telluration Azo compounds 8-Hydroxyquinoline Antimicrobial activity Computational and modeling studies A new series of organonotellurium compounds containing azo groups were prepared by new and convenient methods. Reaction of 1-(4-mercuric chloride-2,3-dichlorophenyl)-2-chloro diazine (4) with 8-hydroxyquinoline (5) gave the new organomercury compound 6 in good yield. Telluratio of compound 6 with tellurium tetrabromide in 1:1 and 1:2 mole ratio gave the o-tellurated azo compounds ArTeBr3 (7) and Ar2TeBr2 (9), respectively. Reduction of both ArTeBr3 and Ar2TeBr2 by hydrazine hydrate gave the ditelluride 8, and telluride 10, respectively. The synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Klebsiella pneumonia, Salmonella spp., Streptococcus spp. and Bacillus cereus. Additionally, the prepared compounds were tested for antifungal activity against Candida sp., Aspergillus multi and Aspergillus niger. All compounds exhibited good antibacterial and antifungal activity. Computational study of the new compounds was calculated using Gaussian 09 program package. Molecular modeling studies were performed and showed hydrogen binding and hydrophobic interactions. Atlanta Publishing House LLC 2015-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1254 10.5155/eurjchem.6.4.374-380.1254 European Journal of Chemistry; Vol. 6 No. 4 (2015): December 2015; 374-380 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1254/pdf_1254