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oai:ojs.www.eurjchem.com:article/1316 2015-12-31T11:02:45Z eurjchem:ART driver

Design and synthesis of new thiophene derivatives together with their antitumor evaluations Mahmoud, Mahmoud Ali Abdelaziz Pyrazole Thiophene Cytotoxicity Breast cancer Antitumor activity Benzo[b]thiophene A series of new thiophene derivatives (3a,b) have been prepared by the reaction of acetylacetone with either cyanoacetanilide or 2-cyano-N-(p-tolyl)acetamide and elemental sulfur in the presence of triethylamine as basic catalyst. The two synthesized compounds were used to further synthesize new thiophene derivatives. The structures of all the newly synthesized products have been established on the basis of analytical and spectral data. The antitumor activity of the newly thiophene derivatives was evaluated against six human cancer cell lines, namely gastric cancer (NUGC), colon cancer (DLD1), liver cancer (HA22T and HEPG2), nasopharyngeal carcinoma (HONE1), breast cancer (MCF) and normal fibroblast cells (WI38). Atlanta Publishing House LLC 2015-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1316 10.5155/eurjchem.6.4.444-450.1316 European Journal of Chemistry; Vol. 6 No. 4 (2015): December 2015; 444-450 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1316/pdf_1316