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oai:ojs.www.eurjchem.com:article/1333 2016-03-31T05:10:15Z eurjchem:ART driver

Synthesis, characterization and antibacterial evaluation of novel 2-mercaptobenzothiazole derivatives bearing 2-aminonicotinonitrile moiety Mahdi, Monther Faisal Al-Smaism, Rafah Fadhil Ibrahim, Noor Waleed 2-MBT Chalcones Microwave Malononitrile Ultrasonic method 2-Aminonicotinonitrile An efficient methods has been described for the synthesis of new 2-aminonicotinonitrile derivatives (6a-f) bearing benzothiazole nucleus by solvent free microwave or ultrasound irradiation. The reaction proceeds via one-pot four-component by cyclo condensation reaction of heterocyclic methyl ketones (4a), malononitrile, ammonium acetate and aryl aldehydes. Chalcones intermediate and final compounds were also synthesized by conventional methods, the result confirms that microwave method showed higher yield and purity than conventional one. The synthesized compounds were characterized by FT-IR spectroscopy and 1H NMR. Antibacterial activities of the synthesized compounds have been tested against four different types of bacteria; most of the tested compounds showed significant biological activities. Atlanta Publishing House LLC 2016-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1333 10.5155/eurjchem.7.1.8-13.1333 European Journal of Chemistry; Vol. 7 No. 1 (2016): March 2016; 8-13 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1333/pdf_1333