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Synthesis, structural and spectral characterization, and in vitro nuclease activity of new thiosemicarbazone derivatives Hussein, Mouayed Abdulaali Guan, Teoh Siang DNA cleavage Gel electrophoresis Thiosemicarbazone Electronic transition Fluorescence emission X-ray single crystal structure Two new compounds, (E)-2-(3-ethoxy-2-hydroxybenzylidene)hydrazinecarbothioamide (1) and (E)-N-ethyl-2-((2-hydroxynaphthalen-1-yl)methylene)hydrazinecarbothioamide (2) have been synthesized. The prepared compounds have been characterized by CHN analysis, FT-IR, UV-Vis, 1H and 13C NMR spectroscopic techniques as well as the fluorescence emission spectroscopy. The molecular structures of the compounds have also been determined by X-ray single crystal diffraction analysis. The crystal structures revealed that the compounds are remain as a thione form in the solid state and are different in their geometrical, conformational and symmetrical structures. The nuclease activity of compounds to cleave pBR 322 has been investigated using agarose gel electrophoresis assay. The compound 2 revealed a significant nuclease activity which was attributed to the lipophilic properties that provided by substituent moieties of the compound. Atlanta Publishing House LLC 2016-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/plain text/plain https://www.eurjchem.com/index.php/eurjchem/article/view/1354 10.5155/eurjchem.7.1.1-7.1354 European Journal of Chemistry; Vol. 7 No. 1 (2016): March 2016; 1-7 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1354/pdf_1354 https://www.eurjchem.com/index.php/eurjchem/article/view/1354/2568 https://www.eurjchem.com/index.php/eurjchem/article/view/1354/2569