2026-05-14T06:20:17Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1372 2016-03-31T05:10:15Z eurjchem:ART driver

Synthesis, characterization, mass spectral fragmentation, thermal study and biological evaluation of new Schiff base ligand and its metal(II) complexes derived from 4-(diethylamino)salicylaldehyde and thiazole moiety Yernale, Nagesh Gunvanthrao Udayagiri, Mahadev Dhanraj Mruthyunjayaswam, Bennikallu Hire Mathada Thiazole Schiff base Mass fragmentation Antibacterial activity Transition metal complexes 4-(Diethylamino)salicylaldehyde A new Schiff base ligand, 2-(4-(diethylamino)-2-hydroxybenzylidene)-N-(4-phenylthiazol-2-yl) hydrazinecarboxamide (L) and its copper(II), cobalt(II), nickel(II) and zinc(II) complexes were prepared and characterized by analytical and spectroscopic methods. The analytical data suggests the composition of the metal complexes to be 1:2 of the type [ML2] for copper(II), cobalt(II) and nickel(II) complexes and 1:1 stoichiometry of the type [MLCl] for zinc(II) complex, where L is the deprotonated Schiff base ligand. The conductance measurement data indicates that all the metal complexes are non-electrolytes. The antioxidant activity of all the compounds was evaluated using the DPPH assay. The Schiff base ligand (L) and its copper(II), cobalt(II) complexes are found to be good antioxidants. The antibacterial and antifungal activity was performed by agar diffusion methods. All the metal(II) complexes inhibited the growth of bacteria and fungi. Also, brine shrimp bioassay was also carried out to study the in vitro cytotoxic properties, the copper(II) and zinc(II) complexes showed good cytotoxic property. Atlanta Publishing House LLC 2016-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1372 10.5155/eurjchem.7.1.56-65.1372 European Journal of Chemistry; Vol. 7 No. 1 (2016): March 2016; 56-65 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1372/pdf_1372