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oai:ojs.www.eurjchem.com:article/1374 2016-03-31T05:10:15Z eurjchem:ART driver

Synthesis, antimicrobial activity and modelling studies of some new metal complexes of Schiff base derived from sulphonamide drug in vitro Al-Masoudi, Wasfi Aboud Faaz, Rana Adnan Al-Asadi, Rafid Hmedan Jabbar, Hazim Saad Synthesis Schiff base Sulfonamide Metal complexes Modeling studies Antimicrobial activity Palladium(II) and cobalt(II) complexes of Schiff base derived from 4-aminobenzene sulfonamide (Sulfonamide drug) were prepared by convenient method. Reaction of sulfonamide with 2-hydroxy-1-naphthaldehyde gave the Schiff base compound 1 in good yield. Treatment of compound 1 with CoCl2.6H2O and PdCl2yielded new metal complexes 2 and 3, respectively. The synthesized compounds were screened for their antibacterial activity against Escherichia coli, Bacillus cereus, Salmonella spp. and Staphylococcus aureus. Additionally, the compounds were tested for antifungal activity against Aspergillus niger and Candida albicans. Some compounds exhibited good antibacterial and antifungal activity. Molecular modeling studies were performed and showed hydrogen binding and hydrophobic interactions. Atlanta Publishing House LLC 2016-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1374 10.5155/eurjchem.7.1.102-106.1374 European Journal of Chemistry; Vol. 7 No. 1 (2016): March 2016; 102-106 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1374/pdf_1374