2026-05-15T18:50:22Z https://www.eurjchem.com/index.php/eurjchem/oai

oai:ojs.www.eurjchem.com:article/1407 2023-05-22T03:43:51Z eurjchem:ART driver

Determination of binary mixture of ibuprofen and famotidine by different spectrophotometric methods Al-Shibly, Ahmed Aqeel Monir, Hany Hunter El-Ghobashy, Mohamed Refaat Amer, Sawsan Mohamed Ibuprofen Famotidine Ratio spectra Dual wavelength Ratio subtraction Spectrophotometric method Four simple and specific spectrophotometric methods were developed and validated for the simultaneous determination of binary mixture of ibuprofen and famotidine, using unified regression equation. The proposed spectrophotometric procedures including, derivative ratio, ratio subtraction, dual wavelength and mean centering of ratio spectra do not require any separation steps. Accuracy, precision and linearity ranges of the proposed methods were determined and the specificity was assessed by analysing synthetic mixtures of both drugs. The methods were applied to a pharmaceutical formulation and the results obtained showed that there is no significant difference between the proposed methods and the reported one regarding both accuracy and precision. Atlanta Publishing House LLC 2016-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.eurjchem.com/index.php/eurjchem/article/view/1407 10.5155/eurjchem.7.2.161-165.1407 European Journal of Chemistry; Vol. 7 No. 2 (2016): June 2016; 161-165 2153-2257 2153-2249 eng https://www.eurjchem.com/index.php/eurjchem/article/view/1407/pdf_1407